Non-cognate ligands of hepatitis C virus envelope broadly neutralizing antibodies induce virus-neutralizing sera in mice

Non-cognate ligands of hepatitis C virus envelope broadly neutralizing antibodies induce virus-neutralizing sera in mice

IntroductionThe persistent rise in new Hepatitis C virus (HCV) infections threatens WHO efforts to eliminate HCV infection by 2030. Although direct-acting antiviral (DAA) drugs are efficacious, access remains limited, reinfections occur, and perinatal infections continue to pose long-term complicati...

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Main Authors: Stephen Ian Walimbwa, Shiv Bharadwaj, Petr Kosztyu, Lucie Vankova, Milan Kuchar, Eliska Kopecna, Roman Effenberg, Lukas Drasar, Leona Raskova Kafkova, Petr Maly, Milan Raska
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
hepatitis C
vaccine
mimotope
broadly neutralizing antibodies
myomedins
protein mimicry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1624299/full
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