Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics
Irrespective of medical technology improvements, cancer ranks among the leading causes of mortality worldwide. Although numerous cures and treatments exist, creating alternative cancer therapies with fewer adverse side effects is vital. Since ancient times, plant bioactive compounds have already bee...
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| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Non-coding RNA Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054024001021 |
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| author | Sahreen Sumaira Soundararajan Vijayarathna Manisekaran Hemagirri Mohd Adnan Md Imtaiyaz Hassan Mitesh Patel Reena Gupta Shanmugapriya Yeng Chen Subash C.B. Gopinath Jagat R. Kanwar Sreenivasan Sasidharan |
| author_facet | Sahreen Sumaira Soundararajan Vijayarathna Manisekaran Hemagirri Mohd Adnan Md Imtaiyaz Hassan Mitesh Patel Reena Gupta Shanmugapriya Yeng Chen Subash C.B. Gopinath Jagat R. Kanwar Sreenivasan Sasidharan |
| author_sort | Sahreen Sumaira |
| collection | DOAJ |
| description | Irrespective of medical technology improvements, cancer ranks among the leading causes of mortality worldwide. Although numerous cures and treatments exist, creating alternative cancer therapies with fewer adverse side effects is vital. Since ancient times, plant bioactive compounds have already been used as a remedy to heal cancer. These plant bioactive compounds and their anticancer activity can also deregulate the microRNAs (miRNAs) in the cancerous cells. Therefore, the deregulation of miRNAs in cancer cells by plant bioactive compounds and the usage of the related miRNA could be a promising approach for cancer cure, mainly to prevent cancer and overcome chemotherapeutic side effect problems. Hence, this review highlights the function of plant bioactive compounds as an anticancer agent through the underlying mechanism that alters the miRNA expression in cancer cells, ultimately leading to apoptosis. Moreover, this review provides insight into using plant bioactive compounds -driven miRNAs as an anticancer agent to develop miRNA-based cancer gene therapy. They can be the potential resource for gene therapy and novel strategies targeting cancer therapeutics. |
| format | Article |
| id | doaj-art-8cd371ad9e1f40dbbc09f89cd78de7c8 |
| institution | DOAJ |
| issn | 2468-0540 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj-art-8cd371ad9e1f40dbbc09f89cd78de7c82025-08-20T02:49:56ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402024-12-01941140115810.1016/j.ncrna.2024.06.003Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeuticsSahreen Sumaira0Soundararajan Vijayarathna1Manisekaran Hemagirri2Mohd Adnan3Md Imtaiyaz Hassan4Mitesh Patel5Reena Gupta6 Shanmugapriya7Yeng Chen8Subash C.B. Gopinath9Jagat R. Kanwar10Sreenivasan Sasidharan11Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, USM, 11800, Pulau Pinang, MalaysiaInstitute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, USM, 11800, Pulau Pinang, MalaysiaInstitute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, USM, 11800, Pulau Pinang, MalaysiaDepartment of Biology, College of Science, University of Hail, Hail, P.O. Box 2440, Saudi ArabiaCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, IndiaResearch and Development Cell and Department of Biotechnology, Parul Institute of Applied Sciences, Parul University, Vadodara, 391760, Gujarat, IndiaInstitute of Pharmaceutical Research, Department. Pharmaceutical Research, GLA University, Mathura, IndiaInstitute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, USM, 11800, Pulau Pinang, MalaysiaDepartment of Oral & Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, MalaysiaFaculty of Chemical Engineering Technology, Universiti Malaysia Perlis, Perlis, MalaysiaDepartment of Biochemistry, All India Institute of Medical Sciences (AIIMS), 174001, Bilaspur, Himachal Pradesh, IndiaInstitute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, USM, 11800, Pulau Pinang, Malaysia; Corresponding author. Institute for Research in Molecular Medicine, Universiti Sains Malaysia, 11800, USM, Pulau Pinang, Malaysia.Irrespective of medical technology improvements, cancer ranks among the leading causes of mortality worldwide. Although numerous cures and treatments exist, creating alternative cancer therapies with fewer adverse side effects is vital. Since ancient times, plant bioactive compounds have already been used as a remedy to heal cancer. These plant bioactive compounds and their anticancer activity can also deregulate the microRNAs (miRNAs) in the cancerous cells. Therefore, the deregulation of miRNAs in cancer cells by plant bioactive compounds and the usage of the related miRNA could be a promising approach for cancer cure, mainly to prevent cancer and overcome chemotherapeutic side effect problems. Hence, this review highlights the function of plant bioactive compounds as an anticancer agent through the underlying mechanism that alters the miRNA expression in cancer cells, ultimately leading to apoptosis. Moreover, this review provides insight into using plant bioactive compounds -driven miRNAs as an anticancer agent to develop miRNA-based cancer gene therapy. They can be the potential resource for gene therapy and novel strategies targeting cancer therapeutics.http://www.sciencedirect.com/science/article/pii/S2468054024001021Anti-cancerGene therapymiRNAApoptosisPlant bioactive compounds |
| spellingShingle | Sahreen Sumaira Soundararajan Vijayarathna Manisekaran Hemagirri Mohd Adnan Md Imtaiyaz Hassan Mitesh Patel Reena Gupta Shanmugapriya Yeng Chen Subash C.B. Gopinath Jagat R. Kanwar Sreenivasan Sasidharan Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics Non-coding RNA Research Anti-cancer Gene therapy miRNA Apoptosis Plant bioactive compounds |
| title | Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics |
| title_full | Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics |
| title_fullStr | Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics |
| title_full_unstemmed | Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics |
| title_short | Plant bioactive compounds driven microRNAs (miRNAs): A potential source and novel strategy targeting gene and cancer therapeutics |
| title_sort | plant bioactive compounds driven micrornas mirnas a potential source and novel strategy targeting gene and cancer therapeutics |
| topic | Anti-cancer Gene therapy miRNA Apoptosis Plant bioactive compounds |
| url | http://www.sciencedirect.com/science/article/pii/S2468054024001021 |
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