Design and evaluation of modified gelatin films to address the aging problem of soft capsule shells
The objective of this experiment was to modify the structure of gelatin using succinic anhydride in order to address the issue of aging caused by the gelatin cross-linking reaction. The addition of succinic anhydride to the gelatin solution enabled the initiation of a chemical reaction, resulting in...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Polymer Testing |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S014294182500073X |
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| author | Chungang Zhang Chao Xie Huimin Fu Jiahui Li Yang Wang Minyuan Tian Heng Hu |
| author_facet | Chungang Zhang Chao Xie Huimin Fu Jiahui Li Yang Wang Minyuan Tian Heng Hu |
| author_sort | Chungang Zhang |
| collection | DOAJ |
| description | The objective of this experiment was to modify the structure of gelatin using succinic anhydride in order to address the issue of aging caused by the gelatin cross-linking reaction. The addition of succinic anhydride to the gelatin solution enabled the initiation of a chemical reaction, resulting in the formation of succinylated gelatin. The structure of the succinylated gelatin was characterized by Fourier transform infrared spectral analysis (FT-IR) and nuclear magnetic resonance spectroscopy (NMR). By comparing the disintegration time and mechanical properties of formaldehyde-treated gelatin, it was found that the disintegration time of formaldehyde-treated gelatin was much higher than that of acylated gelatin, and the change in mechanical properties was more pronounced. The stability and hygroscopicity of the two films before and after succinic anhydride modification were measured. The results of the moisture diffusion mechanism and scanning electron microscopy (SEM) analysis demonstrated that the moisture absorption capacity of the two films was essentially the same. The findings demonstrated that the alteration of the gelatin configuration through succinic anhydride incorporation exhibited a discernible anti-formaldehyde impact. Moreover, the hygroscopic ability of the two types of films was largely unchanged before and after the succinic anhydride modification, indicating that the modified gelatin had no significant impact on its hygroscopic property. In light of these findings, we postulate that the modification of gelatin with succinic anhydride may prove an effective strategy for achieving an anti-ageing effect. |
| format | Article |
| id | doaj-art-8cd224e7e5d743979367630c3112e8c0 |
| institution | OA Journals |
| issn | 1873-2348 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Polymer Testing |
| spelling | doaj-art-8cd224e7e5d743979367630c3112e8c02025-08-20T01:54:16ZengElsevierPolymer Testing1873-23482025-04-0114510875910.1016/j.polymertesting.2025.108759Design and evaluation of modified gelatin films to address the aging problem of soft capsule shellsChungang Zhang0Chao Xie1Huimin Fu2Jiahui Li3Yang Wang4Minyuan Tian5Heng Hu6College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China; Department of Pharmacy, Changzhi Medical College, Changzhi, China; Qimeng Co., LTD, Chifeng, China; Corresponding author. College of Pharmacy, Liaoning University of Traditional Chinese Medicine, No. 77, Life One Road, DD port, Dalian, 116600, China.College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, ChinaCollege of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, ChinaCollege of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, ChinaCollege of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, ChinaCollege of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, ChinaCollege of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, ChinaThe objective of this experiment was to modify the structure of gelatin using succinic anhydride in order to address the issue of aging caused by the gelatin cross-linking reaction. The addition of succinic anhydride to the gelatin solution enabled the initiation of a chemical reaction, resulting in the formation of succinylated gelatin. The structure of the succinylated gelatin was characterized by Fourier transform infrared spectral analysis (FT-IR) and nuclear magnetic resonance spectroscopy (NMR). By comparing the disintegration time and mechanical properties of formaldehyde-treated gelatin, it was found that the disintegration time of formaldehyde-treated gelatin was much higher than that of acylated gelatin, and the change in mechanical properties was more pronounced. The stability and hygroscopicity of the two films before and after succinic anhydride modification were measured. The results of the moisture diffusion mechanism and scanning electron microscopy (SEM) analysis demonstrated that the moisture absorption capacity of the two films was essentially the same. The findings demonstrated that the alteration of the gelatin configuration through succinic anhydride incorporation exhibited a discernible anti-formaldehyde impact. Moreover, the hygroscopic ability of the two types of films was largely unchanged before and after the succinic anhydride modification, indicating that the modified gelatin had no significant impact on its hygroscopic property. In light of these findings, we postulate that the modification of gelatin with succinic anhydride may prove an effective strategy for achieving an anti-ageing effect.http://www.sciencedirect.com/science/article/pii/S014294182500073XSuccinylated gelatin filmsAging problemCross-linking reactionFT-IRNMRFickian model |
| spellingShingle | Chungang Zhang Chao Xie Huimin Fu Jiahui Li Yang Wang Minyuan Tian Heng Hu Design and evaluation of modified gelatin films to address the aging problem of soft capsule shells Polymer Testing Succinylated gelatin films Aging problem Cross-linking reaction FT-IR NMR Fickian model |
| title | Design and evaluation of modified gelatin films to address the aging problem of soft capsule shells |
| title_full | Design and evaluation of modified gelatin films to address the aging problem of soft capsule shells |
| title_fullStr | Design and evaluation of modified gelatin films to address the aging problem of soft capsule shells |
| title_full_unstemmed | Design and evaluation of modified gelatin films to address the aging problem of soft capsule shells |
| title_short | Design and evaluation of modified gelatin films to address the aging problem of soft capsule shells |
| title_sort | design and evaluation of modified gelatin films to address the aging problem of soft capsule shells |
| topic | Succinylated gelatin films Aging problem Cross-linking reaction FT-IR NMR Fickian model |
| url | http://www.sciencedirect.com/science/article/pii/S014294182500073X |
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