Aux/IAAs: specificity and redundancy
Auxin/Indole-3-Acetic Acids(Aux/IAAs), a class of early auxin-responsive genes, encode short-lived nuclear proteins that play pivotal roles in auxin signaling. In vascular plants, Aux/IAA genes form large families-such as the 29 members in Arabidopsis, exhibiting both functional redundancy and speci...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Plant Signaling & Behavior |
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| Online Access: | http://dx.doi.org/10.1080/15592324.2025.2530541 |
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| author | Qiming Wen Qian Gong Huaying Yu Panyu Yang |
| author_facet | Qiming Wen Qian Gong Huaying Yu Panyu Yang |
| author_sort | Qiming Wen |
| collection | DOAJ |
| description | Auxin/Indole-3-Acetic Acids(Aux/IAAs), a class of early auxin-responsive genes, encode short-lived nuclear proteins that play pivotal roles in auxin signaling. In vascular plants, Aux/IAA genes form large families-such as the 29 members in Arabidopsis, exhibiting both functional redundancy and specificity. Canonical Aux/IAA proteins contain four conserved domains and mediate nuclear auxin response by interacting with Transport Inhibitor Response 1/Auxin Signaling F‐box (TIR1/AFB) auxin receptors and Auxin Response Factor (ARF) transcription factors. Loss- and gain-of-function mutants have been instrumental in dissecting the roles of individual Aux/IAAs. Recent studies have also uncovered the mechanism of non-canonical Aux/IAAs, which lack one or more conserved domains and regulate auxin signaling through distinct pathways. This review summarizes the structural features of Aux/IAA proteins, the functional diversity of non-canonical members, the phenotypic effects of their mutants, and their expression patterns. These findings reveal a hierarchical regulatory network of the Aux/IAA gene family in auxin signaling – balancing robustness through functional redundancy and precision and flexibility through member-specific functions in plant growth and development. |
| format | Article |
| id | doaj-art-8cd1e8cdc6b940b7ab4d76ddf925798e |
| institution | Kabale University |
| issn | 1559-2316 1559-2324 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Plant Signaling & Behavior |
| spelling | doaj-art-8cd1e8cdc6b940b7ab4d76ddf925798e2025-08-20T03:50:38ZengTaylor & Francis GroupPlant Signaling & Behavior1559-23161559-23242025-12-0120110.1080/15592324.2025.25305412530541Aux/IAAs: specificity and redundancyQiming Wen0Qian Gong1Huaying Yu2Panyu Yang3Guangxi Normal UniversityGuangxi Normal UniversityGuangxi Normal UniversityGuangxi Normal UniversityAuxin/Indole-3-Acetic Acids(Aux/IAAs), a class of early auxin-responsive genes, encode short-lived nuclear proteins that play pivotal roles in auxin signaling. In vascular plants, Aux/IAA genes form large families-such as the 29 members in Arabidopsis, exhibiting both functional redundancy and specificity. Canonical Aux/IAA proteins contain four conserved domains and mediate nuclear auxin response by interacting with Transport Inhibitor Response 1/Auxin Signaling F‐box (TIR1/AFB) auxin receptors and Auxin Response Factor (ARF) transcription factors. Loss- and gain-of-function mutants have been instrumental in dissecting the roles of individual Aux/IAAs. Recent studies have also uncovered the mechanism of non-canonical Aux/IAAs, which lack one or more conserved domains and regulate auxin signaling through distinct pathways. This review summarizes the structural features of Aux/IAA proteins, the functional diversity of non-canonical members, the phenotypic effects of their mutants, and their expression patterns. These findings reveal a hierarchical regulatory network of the Aux/IAA gene family in auxin signaling – balancing robustness through functional redundancy and precision and flexibility through member-specific functions in plant growth and development.http://dx.doi.org/10.1080/15592324.2025.2530541aux/iaasloss-of-function mutantsgain-of-function mutantsredundancyspecificity |
| spellingShingle | Qiming Wen Qian Gong Huaying Yu Panyu Yang Aux/IAAs: specificity and redundancy Plant Signaling & Behavior aux/iaas loss-of-function mutants gain-of-function mutants redundancy specificity |
| title | Aux/IAAs: specificity and redundancy |
| title_full | Aux/IAAs: specificity and redundancy |
| title_fullStr | Aux/IAAs: specificity and redundancy |
| title_full_unstemmed | Aux/IAAs: specificity and redundancy |
| title_short | Aux/IAAs: specificity and redundancy |
| title_sort | aux iaas specificity and redundancy |
| topic | aux/iaas loss-of-function mutants gain-of-function mutants redundancy specificity |
| url | http://dx.doi.org/10.1080/15592324.2025.2530541 |
| work_keys_str_mv | AT qimingwen auxiaasspecificityandredundancy AT qiangong auxiaasspecificityandredundancy AT huayingyu auxiaasspecificityandredundancy AT panyuyang auxiaasspecificityandredundancy |