Analytical Method for the Simultaneous Determination of Albendazole and Metabolites Using HPLC-PDA: A Validation Study

Analytical Method for the Simultaneous Determination of Albendazole and Metabolites Using HPLC-PDA: A Validation Study

Albendazole is an anthelmintic drug commonly used in animals and humans against nematodes. A sensitive, accurate, precise, and time-saving high-performance liquid chromatography (HPLC) method for the simultaneous determination of albendazole and metabolites (albendazole sulfoxide and albendazole sul...

Full description

Saved in:

Bibliographic Details
Main Authors:	E. Milena Vázquez, Beatriz Romero, Ana M. Sahagún, Cristina López, Raúl de la Puente, José M. Rodríguez, Nélida Fernández, M. José Diez, Raquel Díez
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Series:	Molecules
Subjects:	albendazole albendazole sulfoxide albendazole sulfone EMA guideline HPLC validation
Online Access:	https://www.mdpi.com/1420-3049/30/9/2039
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

LC-MS/MS Analysis of albendazole and its metabolites in animal tissues
by: Ana Csuma,, et al.
Published: (2010-12-01)

Severe forms of neurocysticercosis: treatment with albendazole Formas graves da neurocisticercose: tratamento com albendazol
by: Svetlana Agapejev, et al.
Published: (1996-03-01)

Pourradiculoneurite e neurocisticercose: relato de caso Polyradiculoneuropathy and neurocysticercosis: case report
by: Svetlana Agapejev, et al.
Published: (1996-03-01)

Development of the composition and technology of suspension for oral administration based on a solid dispersion of albendazole
by: Yu. I. Tikhomirova, et al.
Published: (2025-03-01)

EFFECT OF BENZIMIDAZOL ON THE VIABILITY DEVELOPMENT AND SIZES OF ECHINOCOCCUS GRANULOSUS PROTOSCOLICIES IN MICE
by: Abdul jabber Rasmi
Published: (2007-12-01)

A case of alveolar echinococcosis in the liver that ruptured into the pericardium treated by a combination of hepatectomy and albendazole
by: Yoichi Yamamoto, et al.
Published: (2022-04-01)

Development and validation of a RP–HPLC method for quantization studies of albendazole suspension dosage forms of Rombendazol
by: Elena Gabriela Oltean, et al.
Published: (2011-12-01)

Cationized albumin conjugated solid lipid nanoparticles as vectors for delivery of albendazole against cystic echinococcosis
by: Fariba Faizi, et al.
Published: (2024-12-01)

Neurocysticercosis
by: Osvaldo M. Takayanagui
Published: (2013-09-01)

Acute hepatitis in a paediatric patient: immune-mediated drug-induced liver injury or albendazole-induced autoimmune hepatitis?
by: Nataša Dragutinović, et al.
Published: (2022-10-01)

Trichuriasis in Human Patients from Côte d’Ivoire Caused by Novel Trichuris incognita Species with Low Sensitivity to Albendazole/Ivermectin Combination Treatment
by: Abhinaya Venkatesan, et al.
Published: (2025-01-01)

The efficacy of the product Albendazole 10% of gastrointestinal nematode parasitism in sheep tested
by: Florin Stefan Hora, et al.
Published: (2014-12-01)

Сommission test of Effectiveness of the supramolecular complex based on triclabendazole and albendazole at Fasciolosis and gastrointestinal strongylatosis of sheep
by: E. V. Lagereva, et al.
Published: (2020-06-01)

Investigating the Therapeutic Effects of Albendazole, Mebendazole, and Praziquantel Nanocapsules in Hydatid Cyst-Infected Mice
by: Nooshinmehr Soleymani, et al.
Published: (2025-03-01)

Emerging Resistance to Albendazole in Soil-Transmitted Helminths
by: Antonio Ayrton Widiastara, et al.
Published: (2025-07-01)

Adverse effects of long term, continual administration of high doses of albendazole in the treatment of echinococcal disease
by: Jevtić Miodrag, et al.
Published: (2008-01-01)

gdSir2.1 and gdSir2.3 are involved in albendazole resistance in Giardia duodenalis via regulation of the oxidative stress response
by: Adrián Chávez-Cano, et al.
Published: (2025-08-01)

Orbital Cysticercosis
by: Sonam Angmo Bodh, et al.
Published: (2012-10-01)

Effectiveness Therapy to Eliminate Parasite in Cattle at Teaching Factory Polytechnic State of Lampung
by: Vindo Rossy Pertiwi, et al.
Published: (2025-04-01)

Study on the effect of GCY-12 gene on albendazole sensitivity of Haemonchus contortus by RNA interference
by: Xindi Chen, et al.
Published: (2025-05-01)

Black seed oil nanoemulsion containing albendazole against protoscoleces of Echinococcus granulosus: An in vivo study
by: Fatemeh Oroojaian, et al.
Published: (2025-06-01)

Eficácia do albendazol e praziquantel no controle de Anacanthorus penilabiatus (Monogenea: Dactylogyridae), parasito de pacu Piaractus mesopotamicus (Osteichthyes: Characidae). I. Banhos terapêuticos
by: Eduardo Onaka, et al.
Published: (2018-07-01)

Safety and effectiveness of triple-drug therapy with ivermectin, diethylcarbamazine, and albendazole in reducing lymphatic filariasis prevalence and clearing circulating filarial antigens in Mombasa, Kenya
by: Christabel Khaemba, et al.
Published: (2025-02-01)

Combination Therapy of Albendazole and Praziquantel for Treatment of Cardiac and Multiorgan Hydatid Cyst: A Case Report of Novel Treatment and Literature Review
by: Soroush Najdaghi, et al.
Published: (2024-12-01)

Helminth contamination of Wild Ruminants in the West kazakhstan Region and activity of the supramolecular complex of albendazole with Polyvinylpyrrolidone at helminthoses
by: R. S. Karmaliyev, et al.
Published: (2020-06-01)

Impossibility of the treatment of inoperable liver multicystic echinococcosis due to adverse reactions to antihelminitics
by: Mikić Dragan, et al.
Published: (2009-01-01)

Anaphylaxis Due to Hydatid Cyst Rupture
by: Ülkem Koçoğlu Barlas, et al.
Published: (2020-12-01)

Anthelmintic efficiency of medicinal forms of albendazole received on mechanochemical technologies and use of address delivery Drug Delivery System on laboratory model
by: I. I. Glamazdin, et al.
Published: (2016-05-01)

RETRACTED: Anti-relapse chemotherapy in liver echinococcosis
by: A. F. Chernousov, et al.
Published: (2016-12-01)

Regulatory role of lncRNA MSTRG.11540.1 on the novel-m1192-3p/CYP2C70 axis in modulating albendazole resistance in Haemonchus contortus
by: Xindi Chen, et al.
Published: (2025-08-01)

How patient, infection and cysticercus characteristics impact the evolution of Taenia solium larva in the human brain: A unique cyst-level analysis
by: Hongbin Zhang, et al.

Hookworm-related cutaneous larva migrans: our 201st patient
by: Gianluca Nazzaro, et al.
Published: (2017-06-01)

Extraocular Muscle Cysticercosis Masquerading Idiopathic Orbital Inflammatory Syndrome(IOIS)
by: Meenu Babber, et al.
Published: (2012-07-01)

Long-lasting undetected neurocysticercosis
by: Aleksandar Kostić, et al.
Published: (2019-01-01)

Disseminated Peritoneal Hydatidosis: A Case Report
by: Shashi Yadav, et al.
Published: (2025-06-01)

Orbital hydatid cyst and its successful treatment: A case report from Afghanistan
by: Sayed Farooq Hosaini, et al.
Published: (2024-12-01)

Anthelmintic Potential of Discarded Litchi chinensis Seeds: a sustainable approach to agricultural by-product utilization
by: Mustakin Ahmed Shohel, et al.
Published: (2024-12-01)

Preparation and Evaluation of an Oral Administration System of Albendazole-Metal-Organic Framework Based on Dual Response to pH and Enzymes
by: Weiqi Liu, et al.
Published: (2025-05-01)

The Results of Giardiasis Treatment Using Giardicidal Drugs and their Combination with Probiotics in Children: A Retrospective Cohort Study
by: Olga G. Kimirilova, et al.
Published: (2018-10-01)

Echoes of Dormancy: Anomic Aphasia Unveils Neurocysticercosis Reactivation in a Patient on Semaglutide
by: Marcos Osorio Borjas, et al.
Published: (2025-05-01)