The role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancer
Breast cancer is the most prevalent malignancy among women worldwide and is a major contributor to cancer-related mortality. The tumor microenvironment (TME), composed of tumor cells, immune infiltrates, fibroblasts, and vascular components, is critically involved in tumor initiation, metastatic pro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1591745/full |
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| author | Xiaoying Ren Lixiang Zheng Ling Huang Jiangbo Zhao Jiangbo Zhao |
| author_facet | Xiaoying Ren Lixiang Zheng Ling Huang Jiangbo Zhao Jiangbo Zhao |
| author_sort | Xiaoying Ren |
| collection | DOAJ |
| description | Breast cancer is the most prevalent malignancy among women worldwide and is a major contributor to cancer-related mortality. The tumor microenvironment (TME), composed of tumor cells, immune infiltrates, fibroblasts, and vascular components, is critically involved in tumor initiation, metastatic progression, and therapeutic response. In recent years, therapies targeting the TME have undergone rapid advancements, with the objective of enhancing antitumor immunity. Concurrently, mounting evidence underscores the pivotal role of the gut microbiota and its metabolites in modulating host immunity, influencing metabolic homeostasis, inflammation, and immune equilibrium. The composition and diversity of the gut microbiome influence breast cancer progression and patients’ responses to immunotherapy. Therefore, modulating the gut microbiota is a promising strategy to enhance the clinical outcomes of TME-targeted immunotherapies. In this review, we discuss the influence of gut microbiota and its derived metabolites on breast cancer progression and immunotherapy prognosis and explore potential strategies to optimize immunotherapy through gut microbiota modulation. |
| format | Article |
| id | doaj-art-8cd15836b3d34f87afd8d783d8dce1de |
| institution | OA Journals |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-8cd15836b3d34f87afd8d783d8dce1de2025-08-20T02:29:15ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-05-011610.3389/fmicb.2025.15917451591745The role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancerXiaoying Ren0Lixiang Zheng1Ling Huang2Jiangbo Zhao3Jiangbo Zhao4College of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, ChinaCollege of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, ChinaCollege of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, ChinaJiangxi Provincial Children’s Hospital, Nanchang, ChinaThe Affiliated Children’s Hospital of Nanchang Medical College, Nanchang, ChinaBreast cancer is the most prevalent malignancy among women worldwide and is a major contributor to cancer-related mortality. The tumor microenvironment (TME), composed of tumor cells, immune infiltrates, fibroblasts, and vascular components, is critically involved in tumor initiation, metastatic progression, and therapeutic response. In recent years, therapies targeting the TME have undergone rapid advancements, with the objective of enhancing antitumor immunity. Concurrently, mounting evidence underscores the pivotal role of the gut microbiota and its metabolites in modulating host immunity, influencing metabolic homeostasis, inflammation, and immune equilibrium. The composition and diversity of the gut microbiome influence breast cancer progression and patients’ responses to immunotherapy. Therefore, modulating the gut microbiota is a promising strategy to enhance the clinical outcomes of TME-targeted immunotherapies. In this review, we discuss the influence of gut microbiota and its derived metabolites on breast cancer progression and immunotherapy prognosis and explore potential strategies to optimize immunotherapy through gut microbiota modulation.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1591745/fullbreast cancertumor microenvironmentimmunotherapygut microbiotadietary interventionfecal microbiota transplantation |
| spellingShingle | Xiaoying Ren Lixiang Zheng Ling Huang Jiangbo Zhao Jiangbo Zhao The role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancer Frontiers in Microbiology breast cancer tumor microenvironment immunotherapy gut microbiota dietary intervention fecal microbiota transplantation |
| title | The role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancer |
| title_full | The role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancer |
| title_fullStr | The role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancer |
| title_full_unstemmed | The role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancer |
| title_short | The role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancer |
| title_sort | role of the gut microbiota in shaping the tumor microenvironment and immunotherapy of breast cancer |
| topic | breast cancer tumor microenvironment immunotherapy gut microbiota dietary intervention fecal microbiota transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1591745/full |
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