TLR7 rs179008 (A/T) and TLR7 rs3853839 (C/G) polymorphisms are associated with variations in IFN-α levels in HTLV-1 infection

TLR7 rs179008 (A/T) and TLR7 rs3853839 (C/G) polymorphisms are associated with variations in IFN-α levels in HTLV-1 infection

IntroductionTLR7 detects the presence of single-stranded RNA (ssRNA) viruses, including human T-lymphotropic virus 1 (HTLV-1), and triggers antiviral and inflammatory responses that are responsible for infection control. Genetic variations in the TLR7 gene may alter cytokine production and influence...

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Main Authors: Emmanuelle Giuliana Mendes Santana, Fabiane dos Santos Ferreira, Wandrey Roberto dos Santos Brito, Felipe Teixeira Lopes, Aline Cecy Rocha de Lima, Gabriel dos Santos Pereira Neto, Ednelza da Silva Graça Amoras, Sandra Souza Lima, Carlos Araujo da Costa, Maísa Silva Souza, Ricardo Ishak, Izaura Maria Vieira Cayres-Vallinoto, Antonio Carlos Rosário Vallinoto, Maria Alice Freitas Queiroz
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
HTLV-I infection
toll-like receptor 7
polymorphism genetic
gene expression profile
interferon-alpha
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1462352/full
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