Effect of Vitamin D and Calcium Supplementation on Menstrual Abnormalities, Follicular Response and Metabolic Status in Polycystic Ovary Syndrome: A Systematic Review
Introduction: Polycystic Ovary Syndrome (PCOS) is a prevalent hormonal disorder affecting women. It presents with irregular periods, high levels of male hormones and multiple cysts on the ovaries. Metabolic disruptions related to PCOS consist of insulin resistance, obesity and dyslipidaemia. Rec...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2025-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/20733/78879_CE[Ra1]_F(SL)_QC_PF1(AG_SS)_PFA(IS)_PB(AG_IS)_PN(IS).pdf |
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| Summary: | Introduction: Polycystic Ovary Syndrome (PCOS) is a prevalent
hormonal disorder affecting women. It presents with irregular
periods, high levels of male hormones and multiple cysts on
the ovaries. Metabolic disruptions related to PCOS consist of
insulin resistance, obesity and dyslipidaemia. Recent studies
show that supplementing with vitamin D and calcium could
benefit metabolic health, menstrual cycle regularity and follicular
growth in women with PCOS.
Aim: To analyse the effectiveness of Vitamin D and Calcium on
metabolic parameters, menstrual cycles and follicular response
in patients with PCOS.
Materials and Methods: The studies were reviewed following
the Preferred Reporting Items for Systematic Reviews and MetaAnalyses (PRISMA) guidelines. A thorough literature search
was conducted in databases including PubMed, Pub Med
Central, Web of Science, Scopus, Cochrane Central Register
of Controlled Trials (CENTRAL), Evidence-based Medicine
Reviews (EBMR), and Google Scholar. The quality of the studies
was evaluated using the Joanna Briggs Institute (JBI) checklist
for systematic reviews and research syntheses and the data
were analysed using a narrative approach.
Results: The systematic review of 12 experimental studies
showed mixed results on the effects of vitamin D and calcium
supplementation in women with PCOS. Some studies reported
improved insulin sensitivity, lipid profiles and menstrual cycle
regularity, while others found inconsistent outcomes in follicular
development and ovarian morphology, with some showing
improvement and others finding no significant changes
compared to controls.
Conclusion: The present systematic review suggests that
vitamin D and calcium supplementation can potentially improve
metabolic status in women with PCOS, but the effects on
menstrual cycle abnormalities and follicular response are
inconsistent. The variability in study outcomes highlights the
need for personalised supplementation strategies and further
research to determine the optimal treatment approach for
improving both metabolic and reproductive health in women
with PCOS. |
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| ISSN: | 2249-782X 0973-709X |