Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence
Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant o...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/9451950 |
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| _version_ | 1850211294756470784 |
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| author | Adam Kuba Ludek Raida |
| author_facet | Adam Kuba Ludek Raida |
| author_sort | Adam Kuba |
| collection | DOAJ |
| description | Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant obstacle in successful HSCT outcome. This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence. |
| format | Article |
| id | doaj-art-8cc74fed7dde4cd88b7a30f50469dc9b |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8cc74fed7dde4cd88b7a30f50469dc9b2025-08-20T02:09:35ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/94519509451950Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular SenescenceAdam Kuba0Ludek Raida1Department of Hemato-Oncology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech RepublicDepartment of Hemato-Oncology, University Hospital and Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech RepublicGraft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant obstacle in successful HSCT outcome. This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence.http://dx.doi.org/10.1155/2018/9451950 |
| spellingShingle | Adam Kuba Ludek Raida Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence Mediators of Inflammation |
| title | Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence |
| title_full | Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence |
| title_fullStr | Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence |
| title_full_unstemmed | Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence |
| title_short | Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence |
| title_sort | graft versus host disease from basic pathogenic principles to dna damage response and cellular senescence |
| url | http://dx.doi.org/10.1155/2018/9451950 |
| work_keys_str_mv | AT adamkuba graftversushostdiseasefrombasicpathogenicprinciplestodnadamageresponseandcellularsenescence AT ludekraida graftversushostdiseasefrombasicpathogenicprinciplestodnadamageresponseandcellularsenescence |