The use of transpulmonary contrast echocardiography: A first experience in Serbia
Background/Aim. Contrast echocardiography (CE) is an echocardiographic modality where ultrasound contrast echocardiographic agent (CEA) is introduced peripherally for the image enhancement. The aim of this study was to present the initial clinical experience of the use of CEA Optison™ (GE Healthcare...
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2021-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000020S.pdf |
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| author | Stojšić-Milosavljević Anastrazija Ilić Aleksandra Stojšić Snežana Ivanović Vladimir Milićević Jelena Kovač Robert Stefanović Maja Tadić Snežana Miljković Tatjana Bjelobrk Marija Dabović Dragana Živkov-Šaponja Dragoslava Petrović Milovan Aleksandar Redžek |
| author_facet | Stojšić-Milosavljević Anastrazija Ilić Aleksandra Stojšić Snežana Ivanović Vladimir Milićević Jelena Kovač Robert Stefanović Maja Tadić Snežana Miljković Tatjana Bjelobrk Marija Dabović Dragana Živkov-Šaponja Dragoslava Petrović Milovan Aleksandar Redžek |
| author_sort | Stojšić-Milosavljević Anastrazija |
| collection | DOAJ |
| description | Background/Aim. Contrast echocardiography (CE) is an echocardiographic modality where ultrasound contrast echocardiographic agent (CEA) is introduced peripherally for the image enhancement. The aim of this study was to present the initial clinical experience of the use of CEA Optison™ (GE Healthcare, Princeton, NJ) at the Institute for Cardiovascular Diseases of Vojvodina, Serbia and prospectively monitor the occurrence of possible side effects. Methods. A total of 357 patients were referred for resting or stress echocardiographic examinations, with an approved indication for CEA administration. The average age of patients was 63.3 years (range, 21–92 years), 62% of them were men. Most of the patients (77.31%) had some form of ischemic heart diseases. Hypertension was the most frequent risk factor (77.03%), but 57 patients had diabetes mellitus and 33 patients had chronic kidney disease as comorbidity. Most (90.5%) of the patients were on beta blocker therapy, 83.5% of them on angiotensin converting enzyme/angiotensin receptor blockers. Majority (80.3%) of the patients received single or dual (49.5%) antiagregation therapy, 74 (26.3%), of them were on anticoagulation therapy, 55.1% of the patients were taking diuretics. The global ejection fraction (EF) was preserved in 39.85% of them, the majority (136 of them), had left ventricle (LV) impairment, with an EF less than 50%. Patients were followed up for 30 minutes after CEA administration for potential side effects. In 118 patients, vital signs (heart rate, oxygen saturation, body temperature, systolic and diastolic blood pressure) were measured before and 30 minutes after CEA administration. Results. The administration of CEA was not associated with side effects. Diastolic blood pressure drop and heart rate increase were statistically, but not clinically significant (p = 0.027 and p = 0.028, respectively). Conclusion. Changes in analyzed vital signs were clinically non relevant. CE is a safe noninvasive diagnostic modality for patients undergoing rest and stress echocardiography. |
| format | Article |
| id | doaj-art-8cc6d75e21a24e79b95294a74de989d0 |
| institution | DOAJ |
| issn | 0042-8450 2406-0720 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-8cc6d75e21a24e79b95294a74de989d02025-08-20T03:07:01ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502406-07202021-01-0178101036104510.2298/VSP190127020S0042-84502000020SThe use of transpulmonary contrast echocardiography: A first experience in SerbiaStojšić-Milosavljević Anastrazija0Ilić Aleksandra1Stojšić Snežana2Ivanović Vladimir3Milićević Jelena4Kovač Robert5Stefanović Maja6https://orcid.org/0000-0002-7447-3295Tadić Snežana7Miljković Tatjana8Bjelobrk Marija9https://orcid.org/0000-0001-8435-0144Dabović Dragana10Živkov-Šaponja Dragoslava11Petrović Milovan12https://orcid.org/0000-0003-2251-0135Aleksandar Redžek13University of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaInstitute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Ordination Milićević, Novi Sad, SerbiaInstitute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaOrdination Milićević, Novi Sad, Serbia + University Business Academy, Faculty of Pharmacy, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaUniversity of Novi Sad, Faculty of Medicine, Novi Sad, Serbia + Institute of Cardiovascular Diseases of Vojvodina, Sremska Kamenica, SerbiaBackground/Aim. Contrast echocardiography (CE) is an echocardiographic modality where ultrasound contrast echocardiographic agent (CEA) is introduced peripherally for the image enhancement. The aim of this study was to present the initial clinical experience of the use of CEA Optison™ (GE Healthcare, Princeton, NJ) at the Institute for Cardiovascular Diseases of Vojvodina, Serbia and prospectively monitor the occurrence of possible side effects. Methods. A total of 357 patients were referred for resting or stress echocardiographic examinations, with an approved indication for CEA administration. The average age of patients was 63.3 years (range, 21–92 years), 62% of them were men. Most of the patients (77.31%) had some form of ischemic heart diseases. Hypertension was the most frequent risk factor (77.03%), but 57 patients had diabetes mellitus and 33 patients had chronic kidney disease as comorbidity. Most (90.5%) of the patients were on beta blocker therapy, 83.5% of them on angiotensin converting enzyme/angiotensin receptor blockers. Majority (80.3%) of the patients received single or dual (49.5%) antiagregation therapy, 74 (26.3%), of them were on anticoagulation therapy, 55.1% of the patients were taking diuretics. The global ejection fraction (EF) was preserved in 39.85% of them, the majority (136 of them), had left ventricle (LV) impairment, with an EF less than 50%. Patients were followed up for 30 minutes after CEA administration for potential side effects. In 118 patients, vital signs (heart rate, oxygen saturation, body temperature, systolic and diastolic blood pressure) were measured before and 30 minutes after CEA administration. Results. The administration of CEA was not associated with side effects. Diastolic blood pressure drop and heart rate increase were statistically, but not clinically significant (p = 0.027 and p = 0.028, respectively). Conclusion. Changes in analyzed vital signs were clinically non relevant. CE is a safe noninvasive diagnostic modality for patients undergoing rest and stress echocardiography.http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000020S.pdfadverse drug reaction reporting systemscardiovascular diseasescomorbiditycontrast mediaechocardiography |
| spellingShingle | Stojšić-Milosavljević Anastrazija Ilić Aleksandra Stojšić Snežana Ivanović Vladimir Milićević Jelena Kovač Robert Stefanović Maja Tadić Snežana Miljković Tatjana Bjelobrk Marija Dabović Dragana Živkov-Šaponja Dragoslava Petrović Milovan Aleksandar Redžek The use of transpulmonary contrast echocardiography: A first experience in Serbia Vojnosanitetski Pregled adverse drug reaction reporting systems cardiovascular diseases comorbidity contrast media echocardiography |
| title | The use of transpulmonary contrast echocardiography: A first experience in Serbia |
| title_full | The use of transpulmonary contrast echocardiography: A first experience in Serbia |
| title_fullStr | The use of transpulmonary contrast echocardiography: A first experience in Serbia |
| title_full_unstemmed | The use of transpulmonary contrast echocardiography: A first experience in Serbia |
| title_short | The use of transpulmonary contrast echocardiography: A first experience in Serbia |
| title_sort | use of transpulmonary contrast echocardiography a first experience in serbia |
| topic | adverse drug reaction reporting systems cardiovascular diseases comorbidity contrast media echocardiography |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2021/0042-84502000020S.pdf |
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