Computational Drug Repositioning of Mast Cell Stabilizers against Human Protease-Activated Receptor 2 (PAR2) Involved in Rheumatoid Arthritis
Protease-activated receptor 2 (PAR2) plays a pivotal role in activating pain and inflammation pathways in rheumatoid arthritis (RA), contributing to cartilage destruction, synovial inflammation, and heightened joint pain [...]
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-04-01
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| Series: | Proceedings |
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| Online Access: | https://www.mdpi.com/2504-3900/103/1/75 |
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| author | Khushboo Choudhury Ram Singh Purty Kanika Khoba |
| author_facet | Khushboo Choudhury Ram Singh Purty Kanika Khoba |
| author_sort | Khushboo Choudhury |
| collection | DOAJ |
| description | Protease-activated receptor 2 (PAR2) plays a pivotal role in activating pain and inflammation pathways in rheumatoid arthritis (RA), contributing to cartilage destruction, synovial inflammation, and heightened joint pain [...] |
| format | Article |
| id | doaj-art-8cc52415ec5448d3babf9b6bb4bf4ff5 |
| institution | DOAJ |
| issn | 2504-3900 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proceedings |
| spelling | doaj-art-8cc52415ec5448d3babf9b6bb4bf4ff52025-08-20T02:43:02ZengMDPI AGProceedings2504-39002024-04-0110317510.3390/proceedings2024103075Computational Drug Repositioning of Mast Cell Stabilizers against Human Protease-Activated Receptor 2 (PAR2) Involved in Rheumatoid ArthritisKhushboo Choudhury0Ram Singh Purty1Kanika Khoba2Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi 110029, IndiaUniversity School of Biotechnology, Guru Gobind Singh Indraprastha University, New Delhi 110078, IndiaUniversity School of Biotechnology, Guru Gobind Singh Indraprastha University, New Delhi 110078, IndiaProtease-activated receptor 2 (PAR2) plays a pivotal role in activating pain and inflammation pathways in rheumatoid arthritis (RA), contributing to cartilage destruction, synovial inflammation, and heightened joint pain [...]https://www.mdpi.com/2504-3900/103/1/75drug repurposingrheumatoid arthritismast cell stabilizerspain managementmolecular docking |
| spellingShingle | Khushboo Choudhury Ram Singh Purty Kanika Khoba Computational Drug Repositioning of Mast Cell Stabilizers against Human Protease-Activated Receptor 2 (PAR2) Involved in Rheumatoid Arthritis Proceedings drug repurposing rheumatoid arthritis mast cell stabilizers pain management molecular docking |
| title | Computational Drug Repositioning of Mast Cell Stabilizers against Human Protease-Activated Receptor 2 (PAR2) Involved in Rheumatoid Arthritis |
| title_full | Computational Drug Repositioning of Mast Cell Stabilizers against Human Protease-Activated Receptor 2 (PAR2) Involved in Rheumatoid Arthritis |
| title_fullStr | Computational Drug Repositioning of Mast Cell Stabilizers against Human Protease-Activated Receptor 2 (PAR2) Involved in Rheumatoid Arthritis |
| title_full_unstemmed | Computational Drug Repositioning of Mast Cell Stabilizers against Human Protease-Activated Receptor 2 (PAR2) Involved in Rheumatoid Arthritis |
| title_short | Computational Drug Repositioning of Mast Cell Stabilizers against Human Protease-Activated Receptor 2 (PAR2) Involved in Rheumatoid Arthritis |
| title_sort | computational drug repositioning of mast cell stabilizers against human protease activated receptor 2 par2 involved in rheumatoid arthritis |
| topic | drug repurposing rheumatoid arthritis mast cell stabilizers pain management molecular docking |
| url | https://www.mdpi.com/2504-3900/103/1/75 |
| work_keys_str_mv | AT khushboochoudhury computationaldrugrepositioningofmastcellstabilizersagainsthumanproteaseactivatedreceptor2par2involvedinrheumatoidarthritis AT ramsinghpurty computationaldrugrepositioningofmastcellstabilizersagainsthumanproteaseactivatedreceptor2par2involvedinrheumatoidarthritis AT kanikakhoba computationaldrugrepositioningofmastcellstabilizersagainsthumanproteaseactivatedreceptor2par2involvedinrheumatoidarthritis |