The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism
Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a ro...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/390791 |
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| _version_ | 1850211362426322944 |
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| author | Donna M. Gordon Janine Hertzog Santos |
| author_facet | Donna M. Gordon Janine Hertzog Santos |
| author_sort | Donna M. Gordon |
| collection | DOAJ |
| description | Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a role in mitochondrial DNA metabolism. This paper discusses the available data on mitochondrial telomerase with particular emphasis on its effects upon the organellar DNA. |
| format | Article |
| id | doaj-art-8cc0a3fd226c495cacae3c2700e29b8b |
| institution | OA Journals |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-8cc0a3fd226c495cacae3c2700e29b8b2025-08-20T02:09:34ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/390791390791The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA MetabolismDonna M. Gordon0Janine Hertzog Santos1Department of Biological Sciences, Mississippi State University, 114 Harned Hall, 295 Lee Boulevard, Mississippi State, MS 39762, USADepartment of Pharmacology and Physiology, New Jersey Medical School of UMDNJ, 185 South Orange Avenue, Medical Sciences Building, H653, Newark, NJ 07103, USATelomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a role in mitochondrial DNA metabolism. This paper discusses the available data on mitochondrial telomerase with particular emphasis on its effects upon the organellar DNA.http://dx.doi.org/10.4061/2010/390791 |
| spellingShingle | Donna M. Gordon Janine Hertzog Santos The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism Journal of Nucleic Acids |
| title | The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism |
| title_full | The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism |
| title_fullStr | The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism |
| title_full_unstemmed | The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism |
| title_short | The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism |
| title_sort | emerging role of telomerase reverse transcriptase in mitochondrial dna metabolism |
| url | http://dx.doi.org/10.4061/2010/390791 |
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