Catechol-substituted siderophore colistin exhibits superior antimicrobial activity than its unmodified polypeptide counterpart

Catechol-substituted siderophore colistin exhibits superior antimicrobial activity than its unmodified polypeptide counterpart

Abstract Catechol moieties have been covalently coupled to the last-resort polypeptide antibiotic colistin via esterification and amidation reactions, inspired by the superior antimicrobial action of cefiderocol, i.e., a catechol-substituted siderophore cephalosporin. Among the tested strategies, th...

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Bibliographic Details
Main Authors: Sara Bescós-Ramo, Enrique Gámez, María del Mar Encabo-Berzosa, Milagros Piñol, Luis Oriol, Manuel Arruebo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Chemistry
Subjects:
Colistin
Antibiotic
Catechol
Siderophore
Polymyxin E
Esterification
Online Access:https://doi.org/10.1186/s13065-025-01538-7
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