One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasis
Commercially available gelatin sponges are widely used in coagulation-dependent bleeding wounds due to its porous structure that concentrates blood cells, and coagulation factors. However, effective hemostasis cannot currently be achieved under coagulopathic conditions. In this study, we designed a...
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Elsevier
2025-10-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425007410 |
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| author | Yu Wang Xin Li Hanlu Chen Yanfen Shi Yang Li Guochao Zhang Yang Hu Fu-Jian Xu |
| author_facet | Yu Wang Xin Li Hanlu Chen Yanfen Shi Yang Li Guochao Zhang Yang Hu Fu-Jian Xu |
| author_sort | Yu Wang |
| collection | DOAJ |
| description | Commercially available gelatin sponges are widely used in coagulation-dependent bleeding wounds due to its porous structure that concentrates blood cells, and coagulation factors. However, effective hemostasis cannot currently be achieved under coagulopathic conditions. In this study, we designed a procoagulant zein-polyphenol conjugate (ZC) nanoassemblies prepared using an anti-solvent strategy, were directly applied to the surface functionalization of commercially available gelatin sponges. Polyphenols give ZC coatings excellent adhesion and enhance the gelatin sponge's procoagulant properties. Leveraging their distinctive secondary structure, the optimized ZC nanoparticle-coated sponges demonstrated enhanced in vitro hemostatic properties compared to unmodified commercial gelatin sponges and exhibited superior red blood cell and platelet adhesion characteristics. Additionally, the sponges enhanced with the ZC coating exhibited superior hemostatic potential in a femoral-artery-injury model, under both coagulation-dependent and coagulopathic conditions. The current study presents a promising approach for the utilisation of zein-based procoagulant materials for versatile hemostatic materials engineering applications. |
| format | Article |
| id | doaj-art-8cba6da59f164a44a07fd4a279b81592 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-8cba6da59f164a44a07fd4a279b815922025-08-20T03:39:05ZengElsevierMaterials Today Bio2590-00642025-10-013410217110.1016/j.mtbio.2025.102171One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasisYu Wang0Xin Li1Hanlu Chen2Yanfen Shi3Yang Li4Guochao Zhang5Yang Hu6Fu-Jian Xu7State Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR ChinaState Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China; Quzhou Institute for Innovation in Resource Chemical Engineering, Quzhou, 324000, PR ChinaState Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR ChinaDepartment of Pathology, China-Japan Friendship Hospital, Beijing, 100029, PR ChinaState Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR ChinaDepartment of General Surgery, China-Japan Friendship Hospital, Beijing, 100029, PR China; Corresponding author.State Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China; Quzhou Institute for Innovation in Resource Chemical Engineering, Quzhou, 324000, PR China; Corresponding author.State Key Laboratory of Chemical Resource Engineering, Key Lab of Biomedical Materials of Natural Macromolecules (Beijing University of Chemical Technology, Ministry of Education), Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, PR China; Corresponding author.Commercially available gelatin sponges are widely used in coagulation-dependent bleeding wounds due to its porous structure that concentrates blood cells, and coagulation factors. However, effective hemostasis cannot currently be achieved under coagulopathic conditions. In this study, we designed a procoagulant zein-polyphenol conjugate (ZC) nanoassemblies prepared using an anti-solvent strategy, were directly applied to the surface functionalization of commercially available gelatin sponges. Polyphenols give ZC coatings excellent adhesion and enhance the gelatin sponge's procoagulant properties. Leveraging their distinctive secondary structure, the optimized ZC nanoparticle-coated sponges demonstrated enhanced in vitro hemostatic properties compared to unmodified commercial gelatin sponges and exhibited superior red blood cell and platelet adhesion characteristics. Additionally, the sponges enhanced with the ZC coating exhibited superior hemostatic potential in a femoral-artery-injury model, under both coagulation-dependent and coagulopathic conditions. The current study presents a promising approach for the utilisation of zein-based procoagulant materials for versatile hemostatic materials engineering applications.http://www.sciencedirect.com/science/article/pii/S2590006425007410HemostasisSpongeCoatingZeinPolyphenol |
| spellingShingle | Yu Wang Xin Li Hanlu Chen Yanfen Shi Yang Li Guochao Zhang Yang Hu Fu-Jian Xu One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasis Materials Today Bio Hemostasis Sponge Coating Zein Polyphenol |
| title | One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasis |
| title_full | One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasis |
| title_fullStr | One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasis |
| title_full_unstemmed | One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasis |
| title_short | One potent sponge based on plant-protein-polyphenol assemblies for coagulopathic hemostasis |
| title_sort | one potent sponge based on plant protein polyphenol assemblies for coagulopathic hemostasis |
| topic | Hemostasis Sponge Coating Zein Polyphenol |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425007410 |
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