Clinicohematological Profile of Pancytopenia Patients in Tertiary Care Hospital
Introduction: Pancytopenia is a common hematological problem characterized by anemia, leucopenia, and thrombocytopenia. It can be a serious and life-threatening illness. Aim: The objective of this study is to study the clinical presentation and hematological profile in pancytopenia patients. Materia...
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| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_631_25 |
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| author | Deepika Wadhera Priyanka Naryal Tripti Mishra Jaskirat Singh Irbinder K. Bali |
| author_facet | Deepika Wadhera Priyanka Naryal Tripti Mishra Jaskirat Singh Irbinder K. Bali |
| author_sort | Deepika Wadhera |
| collection | DOAJ |
| description | Introduction:
Pancytopenia is a common hematological problem characterized by anemia, leucopenia, and thrombocytopenia. It can be a serious and life-threatening illness.
Aim:
The objective of this study is to study the clinical presentation and hematological profile in pancytopenia patients.
Material and Methods:
The prospective study was done on 50 pancytopenia patients in a tertiary care hospital and the hematological profile was studied. All the cases with hemoglobin [Hb] less than 13 gm/dL in male and female <12 g/dL, total leukocyte count [TLC] less than 4000/cumm, and platelet count less than 150,000/cumm were included in the study.
Result:
It was observed that the majority of the cases had hypercellular marrow [40%], 34% normocellular, and 26% hypocellular marrow. Males [52%] were affected more as compared to females [48%]. Megaloblastic erythroid hyperplasia was found to be the commonest cause for pancytopenia [40%], followed by normoblastic erythroid hyperplasia [5.71%], non-Hodgkin lymphoma [11.42%], acute leukemia [2.85%], MDS [2.85%], malaria [2.85%], hypersplenism 2.85%], lymphoid malignancy [2.85%], focal gelatinous [2.85%], AML [2.85%], megakaryocytic thrombocytopenia [2.85%], and plasma cell myeloma [2.85%].
Conclusion:
It was concluded that the detailed hematological investigations, a thorough clinical examination with hematological studies and bone marrow study is important for understanding the disease process and diagnosing the causes of pancytopenia. |
| format | Article |
| id | doaj-art-8cb965a4caf64e449e2eaceb9e1fee5d |
| institution | OA Journals |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-8cb965a4caf64e449e2eaceb9e1fee5d2025-08-20T02:03:24ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S353S35610.4103/jpbs.jpbs_631_25Clinicohematological Profile of Pancytopenia Patients in Tertiary Care HospitalDeepika WadheraPriyanka NaryalTripti MishraJaskirat SinghIrbinder K. BaliIntroduction: Pancytopenia is a common hematological problem characterized by anemia, leucopenia, and thrombocytopenia. It can be a serious and life-threatening illness. Aim: The objective of this study is to study the clinical presentation and hematological profile in pancytopenia patients. Material and Methods: The prospective study was done on 50 pancytopenia patients in a tertiary care hospital and the hematological profile was studied. All the cases with hemoglobin [Hb] less than 13 gm/dL in male and female <12 g/dL, total leukocyte count [TLC] less than 4000/cumm, and platelet count less than 150,000/cumm were included in the study. Result: It was observed that the majority of the cases had hypercellular marrow [40%], 34% normocellular, and 26% hypocellular marrow. Males [52%] were affected more as compared to females [48%]. Megaloblastic erythroid hyperplasia was found to be the commonest cause for pancytopenia [40%], followed by normoblastic erythroid hyperplasia [5.71%], non-Hodgkin lymphoma [11.42%], acute leukemia [2.85%], MDS [2.85%], malaria [2.85%], hypersplenism 2.85%], lymphoid malignancy [2.85%], focal gelatinous [2.85%], AML [2.85%], megakaryocytic thrombocytopenia [2.85%], and plasma cell myeloma [2.85%]. Conclusion: It was concluded that the detailed hematological investigations, a thorough clinical examination with hematological studies and bone marrow study is important for understanding the disease process and diagnosing the causes of pancytopenia.https://journals.lww.com/10.4103/jpbs.jpbs_631_25anemiabone marrow aspirationleucopeniapancytopeniathrombocytopenia |
| spellingShingle | Deepika Wadhera Priyanka Naryal Tripti Mishra Jaskirat Singh Irbinder K. Bali Clinicohematological Profile of Pancytopenia Patients in Tertiary Care Hospital Journal of Pharmacy and Bioallied Sciences anemia bone marrow aspiration leucopenia pancytopenia thrombocytopenia |
| title | Clinicohematological Profile of Pancytopenia Patients in Tertiary Care Hospital |
| title_full | Clinicohematological Profile of Pancytopenia Patients in Tertiary Care Hospital |
| title_fullStr | Clinicohematological Profile of Pancytopenia Patients in Tertiary Care Hospital |
| title_full_unstemmed | Clinicohematological Profile of Pancytopenia Patients in Tertiary Care Hospital |
| title_short | Clinicohematological Profile of Pancytopenia Patients in Tertiary Care Hospital |
| title_sort | clinicohematological profile of pancytopenia patients in tertiary care hospital |
| topic | anemia bone marrow aspiration leucopenia pancytopenia thrombocytopenia |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_631_25 |
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