Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19
The wide range of symptoms of the coronavirus disease 2019 (COVID-19) makes it challenging to predict the disease evolution using a single parameter. Therefore, to describe the pathophysiological response to SARS-CoV-2 infection in hospitalized patients with severe COVID-19, we compared according to...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2023/3423183 |
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| author | Adriana Martinez-Cuazitl Monica M. Mata-Miranda Miguel Sanchez-Brito Daniel Valencia-Trujillo Amanda M. Avila-Trejo Raul J. Delgado-Macuil Consuelo Atriano-Colorado Francisco Garibay-Gonzalez Virginia Sanchez-Monroy Gustavo J. Vazquez-Zapien |
| author_facet | Adriana Martinez-Cuazitl Monica M. Mata-Miranda Miguel Sanchez-Brito Daniel Valencia-Trujillo Amanda M. Avila-Trejo Raul J. Delgado-Macuil Consuelo Atriano-Colorado Francisco Garibay-Gonzalez Virginia Sanchez-Monroy Gustavo J. Vazquez-Zapien |
| author_sort | Adriana Martinez-Cuazitl |
| collection | DOAJ |
| description | The wide range of symptoms of the coronavirus disease 2019 (COVID-19) makes it challenging to predict the disease evolution using a single parameter. Therefore, to describe the pathophysiological response to SARS-CoV-2 infection in hospitalized patients with severe COVID-19, we compared according to survival or death, the sociodemographic and clinical characteristics, the biochemical and immunological attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra from saliva samples and their correlation with chemometric findings. Herein, we demonstrate that ATR-FTIR spectroscopy allows the description of the events related to cell damage, such as lipids biogenesis and the secondary structure of proteins associated with lactate dehydrogenase and albumin levels. Moreover, humoral (IgM) and cellular (IFN-γ, TNF-α, IL-10, and IL-6) responses were also increased in patients who died from COVID-19. |
| format | Article |
| id | doaj-art-8caf7f3ebfd047f8b826f4a664010ef0 |
| institution | Kabale University |
| issn | 2314-4939 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-8caf7f3ebfd047f8b826f4a664010ef02025-02-03T01:30:44ZengWileyJournal of Spectroscopy2314-49392023-01-01202310.1155/2023/3423183Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19Adriana Martinez-Cuazitl0Monica M. Mata-Miranda1Miguel Sanchez-Brito2Daniel Valencia-Trujillo3Amanda M. Avila-Trejo4Raul J. Delgado-Macuil5Consuelo Atriano-Colorado6Francisco Garibay-Gonzalez7Virginia Sanchez-Monroy8Gustavo J. Vazquez-Zapien9Military School of MedicineMilitary School of MedicineSuperior School of ComputingClinical Microbiology ServiceNational School of Biological SciencesApplied Biotechnology Research CenterMilitary School of MedicineMilitary School of MedicineSuperior School of MedicineMilitary School of MedicineThe wide range of symptoms of the coronavirus disease 2019 (COVID-19) makes it challenging to predict the disease evolution using a single parameter. Therefore, to describe the pathophysiological response to SARS-CoV-2 infection in hospitalized patients with severe COVID-19, we compared according to survival or death, the sociodemographic and clinical characteristics, the biochemical and immunological attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra from saliva samples and their correlation with chemometric findings. Herein, we demonstrate that ATR-FTIR spectroscopy allows the description of the events related to cell damage, such as lipids biogenesis and the secondary structure of proteins associated with lactate dehydrogenase and albumin levels. Moreover, humoral (IgM) and cellular (IFN-γ, TNF-α, IL-10, and IL-6) responses were also increased in patients who died from COVID-19.http://dx.doi.org/10.1155/2023/3423183 |
| spellingShingle | Adriana Martinez-Cuazitl Monica M. Mata-Miranda Miguel Sanchez-Brito Daniel Valencia-Trujillo Amanda M. Avila-Trejo Raul J. Delgado-Macuil Consuelo Atriano-Colorado Francisco Garibay-Gonzalez Virginia Sanchez-Monroy Gustavo J. Vazquez-Zapien Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19 Journal of Spectroscopy |
| title | Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19 |
| title_full | Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19 |
| title_fullStr | Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19 |
| title_full_unstemmed | Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19 |
| title_short | Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19 |
| title_sort | clinical biochemical and atr ftir spectroscopic parameters associated with death or survival in patients with severe covid 19 |
| url | http://dx.doi.org/10.1155/2023/3423183 |
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