The Positive Relationship of Body Mass Index, Drain Production, and Tumor Necrosis Factor-alpha in Stage IIIB Breast Cancer Patients after Modified Radical Mastectomy
Introduction: Modified radical mastectomy (MRM) is one of the treatments for breast cancer (BC). Seroma is a complication that is quite common and can prolong the length of a patient’s stay after MRM which can measure by drain production. Obesity is known to correlate with drain production and the l...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2022-12-01
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| Series: | Biomolecular and Health Science Journal |
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| Online Access: | https://journals.lww.com/10.4103/bhsj.bhsj_12_22 |
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| author | Justinus Dwi Pratjojo Wisnubroto Ester Hans Sunanto |
| author_facet | Justinus Dwi Pratjojo Wisnubroto Ester Hans Sunanto |
| author_sort | Justinus Dwi Pratjojo Wisnubroto |
| collection | DOAJ |
| description | Introduction:
Modified radical mastectomy (MRM) is one of the treatments for breast cancer (BC). Seroma is a complication that is quite common and can prolong the length of a patient’s stay after MRM which can measure by drain production. Obesity is known to correlate with drain production and the levels of tumor necrosis factor-alpha (TNF-α). However, the study on the relationship between obesity with drain production and TNF-α remains unclear.
Methods:
This study was an observational analytic design with a cross-sectional approach. Samples consist of third-stage BC patients after MRM in Saiful Anwar Malang Hospital from June 2020 to September 2020. The blood sample will be taken 24 h after MRM and the value of TNF-α will be measured and drain production will be recorded. The statistical analysis using regression test with a significant level of P < 0.05.
Results:
There were 30 patients in this study with a mean age of 47 ± 4.5 years old. The mean height, weight, and body mass index (BMI) were 59 ± 6.7 kg; 156.90 ± 5.8 cm, and 24.75 ± 4.5 kg/m2, respectively. The most BC type was luminal B (60%). Increasing BMI affects drain production with a contribution of 83%, and 17% from another variable. Increasing BMI also affects TNF-α with a contribution of 45%, and 55% from another variable.
Conclusion:
BMI is one of the factors that affects positively drain production and TNF-α in overweight patients after mastectomy than normoweight patients. |
| format | Article |
| id | doaj-art-8cac998dded34fe98059f3825eb8d244 |
| institution | OA Journals |
| issn | 2620-8636 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Biomolecular and Health Science Journal |
| spelling | doaj-art-8cac998dded34fe98059f3825eb8d2442025-08-20T02:17:57ZengWolters Kluwer – Medknow PublicationsBiomolecular and Health Science Journal2620-86362022-12-015211611910.4103/bhsj.bhsj_12_22The Positive Relationship of Body Mass Index, Drain Production, and Tumor Necrosis Factor-alpha in Stage IIIB Breast Cancer Patients after Modified Radical MastectomyJustinus Dwi Pratjojo WisnubrotoEster Hans SunantoIntroduction: Modified radical mastectomy (MRM) is one of the treatments for breast cancer (BC). Seroma is a complication that is quite common and can prolong the length of a patient’s stay after MRM which can measure by drain production. Obesity is known to correlate with drain production and the levels of tumor necrosis factor-alpha (TNF-α). However, the study on the relationship between obesity with drain production and TNF-α remains unclear. Methods: This study was an observational analytic design with a cross-sectional approach. Samples consist of third-stage BC patients after MRM in Saiful Anwar Malang Hospital from June 2020 to September 2020. The blood sample will be taken 24 h after MRM and the value of TNF-α will be measured and drain production will be recorded. The statistical analysis using regression test with a significant level of P < 0.05. Results: There were 30 patients in this study with a mean age of 47 ± 4.5 years old. The mean height, weight, and body mass index (BMI) were 59 ± 6.7 kg; 156.90 ± 5.8 cm, and 24.75 ± 4.5 kg/m2, respectively. The most BC type was luminal B (60%). Increasing BMI affects drain production with a contribution of 83%, and 17% from another variable. Increasing BMI also affects TNF-α with a contribution of 45%, and 55% from another variable. Conclusion: BMI is one of the factors that affects positively drain production and TNF-α in overweight patients after mastectomy than normoweight patients.https://journals.lww.com/10.4103/bhsj.bhsj_12_22body mass indexbreast cancerdrain productiontumor necrosis factor-alpha |
| spellingShingle | Justinus Dwi Pratjojo Wisnubroto Ester Hans Sunanto The Positive Relationship of Body Mass Index, Drain Production, and Tumor Necrosis Factor-alpha in Stage IIIB Breast Cancer Patients after Modified Radical Mastectomy Biomolecular and Health Science Journal body mass index breast cancer drain production tumor necrosis factor-alpha |
| title | The Positive Relationship of Body Mass Index, Drain Production, and Tumor Necrosis Factor-alpha in Stage IIIB Breast Cancer Patients after Modified Radical Mastectomy |
| title_full | The Positive Relationship of Body Mass Index, Drain Production, and Tumor Necrosis Factor-alpha in Stage IIIB Breast Cancer Patients after Modified Radical Mastectomy |
| title_fullStr | The Positive Relationship of Body Mass Index, Drain Production, and Tumor Necrosis Factor-alpha in Stage IIIB Breast Cancer Patients after Modified Radical Mastectomy |
| title_full_unstemmed | The Positive Relationship of Body Mass Index, Drain Production, and Tumor Necrosis Factor-alpha in Stage IIIB Breast Cancer Patients after Modified Radical Mastectomy |
| title_short | The Positive Relationship of Body Mass Index, Drain Production, and Tumor Necrosis Factor-alpha in Stage IIIB Breast Cancer Patients after Modified Radical Mastectomy |
| title_sort | positive relationship of body mass index drain production and tumor necrosis factor alpha in stage iiib breast cancer patients after modified radical mastectomy |
| topic | body mass index breast cancer drain production tumor necrosis factor-alpha |
| url | https://journals.lww.com/10.4103/bhsj.bhsj_12_22 |
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