Gene Therapy: A step toward advanced orthodontics – A narrative review
Background: Gene therapy deals with the insertion of exogenous genes into a cell to produce the desired therapeutic effect. After the introduction of gene therapy in dentistry, this field is also flourishing rapidly in the branch of orthodontics and dentofacial orthopedics as it can prevent many pre...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | SRM Journal of Research in Dental Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/srmjrds.srmjrds_86_23 |
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| author | Monika Shukla Shalu Jain C. Munish Reddy Pradeep Raghav Kumar Amit Rinchin Yangzom Shivika Garg Aastha Kamrani |
| author_facet | Monika Shukla Shalu Jain C. Munish Reddy Pradeep Raghav Kumar Amit Rinchin Yangzom Shivika Garg Aastha Kamrani |
| author_sort | Monika Shukla |
| collection | DOAJ |
| description | Background:
Gene therapy deals with the insertion of exogenous genes into a cell to produce the desired therapeutic effect. After the introduction of gene therapy in dentistry, this field is also flourishing rapidly in the branch of orthodontics and dentofacial orthopedics as it can prevent many prenatal and postnatal dentofacial anomalies which have the genetical etiology. Despite various animal studies showing promising results, a lot more is left to be explored.
Aim:
This narrative review was conducted to understand the role of gene therapy for various orthodontic procedures and its future scope.
Methods:
Research publications were searched on search engines such as Scopus, PubMed, and Google Scholar, and articles with terms such as “gene therapy, orthodontic tooth movement (OTM), condylar growth, and bone repair” were collected.
Results:
A total of 40 articles were collected and they were further used to formulate this review.
Discussion:
Gene therapy was found to have a major role in orthodontics, especially for: (i) Modulation in OTM, (ii) Alleviation of orthodontic pain, (iii) Enhancement of bone repair and regeneration, (iv) Improving midface hypoplasia by preventing syndromic craniosynostosis, and (v) Modifying condylar growth. |
| format | Article |
| id | doaj-art-8caa551d41f14cf080db04bfb761e106 |
| institution | Kabale University |
| issn | 2772-5243 2772-5251 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | SRM Journal of Research in Dental Sciences |
| spelling | doaj-art-8caa551d41f14cf080db04bfb761e1062025-02-10T10:17:55ZengWolters Kluwer Medknow PublicationsSRM Journal of Research in Dental Sciences2772-52432772-52512023-07-0114314414910.4103/srmjrds.srmjrds_86_23Gene Therapy: A step toward advanced orthodontics – A narrative reviewMonika ShuklaShalu JainC. Munish ReddyPradeep RaghavKumar AmitRinchin YangzomShivika GargAastha KamraniBackground: Gene therapy deals with the insertion of exogenous genes into a cell to produce the desired therapeutic effect. After the introduction of gene therapy in dentistry, this field is also flourishing rapidly in the branch of orthodontics and dentofacial orthopedics as it can prevent many prenatal and postnatal dentofacial anomalies which have the genetical etiology. Despite various animal studies showing promising results, a lot more is left to be explored. Aim: This narrative review was conducted to understand the role of gene therapy for various orthodontic procedures and its future scope. Methods: Research publications were searched on search engines such as Scopus, PubMed, and Google Scholar, and articles with terms such as “gene therapy, orthodontic tooth movement (OTM), condylar growth, and bone repair” were collected. Results: A total of 40 articles were collected and they were further used to formulate this review. Discussion: Gene therapy was found to have a major role in orthodontics, especially for: (i) Modulation in OTM, (ii) Alleviation of orthodontic pain, (iii) Enhancement of bone repair and regeneration, (iv) Improving midface hypoplasia by preventing syndromic craniosynostosis, and (v) Modifying condylar growth.https://journals.lww.com/10.4103/srmjrds.srmjrds_86_23key words: bone repaircondylar growthgene therapyorthodontic tooth movement |
| spellingShingle | Monika Shukla Shalu Jain C. Munish Reddy Pradeep Raghav Kumar Amit Rinchin Yangzom Shivika Garg Aastha Kamrani Gene Therapy: A step toward advanced orthodontics – A narrative review SRM Journal of Research in Dental Sciences key words: bone repair condylar growth gene therapy orthodontic tooth movement |
| title | Gene Therapy: A step toward advanced orthodontics – A narrative review |
| title_full | Gene Therapy: A step toward advanced orthodontics – A narrative review |
| title_fullStr | Gene Therapy: A step toward advanced orthodontics – A narrative review |
| title_full_unstemmed | Gene Therapy: A step toward advanced orthodontics – A narrative review |
| title_short | Gene Therapy: A step toward advanced orthodontics – A narrative review |
| title_sort | gene therapy a step toward advanced orthodontics a narrative review |
| topic | key words: bone repair condylar growth gene therapy orthodontic tooth movement |
| url | https://journals.lww.com/10.4103/srmjrds.srmjrds_86_23 |
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