Insights into next-generation immunotherapy designs and tools: molecular mechanisms and therapeutic prospects

Insights into next-generation immunotherapy designs and tools: molecular mechanisms and therapeutic prospects

Abstract Immunotherapy has revolutionized the oncology treatment paradigm, and CAR-T cell therapy in particular represents a significant milestone in treating hematological malignancies. Nevertheless, tumor resistance due to target heterogeneity or mutation remains a Gordian knot for immunotherapy....

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Main Authors: Hongzhuo Qin, Zhaokai Zhou, Run Shi, Yumiao Mai, Yudi Xu, Fu Peng, Guangyang Cheng, Pengpeng Zhang, Wenjie Chen, Yun Chen, Yajun Chen, Ran Xu, Qiong Lu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Hematology & Oncology
Subjects:
Chimeric antigen receptor
Multi-targets
Logic gate
Adapter CAR
Gene delivery
Gene editing
Online Access:https://doi.org/10.1186/s13045-025-01701-6
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