Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies
The effects of gestational age on placental oxidative balance throughout gestation were investigated in women with uncomplicated pregnancies. Placental tissues were obtained from normal pregnant women who delivered at term or underwent elective pregnancy termination at 6 to 23 + 6 weeks of pregnancy...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2015/276095 |
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| author | Jayasri Basu Bolek Bendek Enyonam Agamasu Carolyn M. Salafia Aruna Mishra Nerys Benfield Ronak Patel Magdy Mikhail |
| author_facet | Jayasri Basu Bolek Bendek Enyonam Agamasu Carolyn M. Salafia Aruna Mishra Nerys Benfield Ronak Patel Magdy Mikhail |
| author_sort | Jayasri Basu |
| collection | DOAJ |
| description | The effects of gestational age on placental oxidative balance throughout gestation were investigated in women with uncomplicated pregnancies. Placental tissues were obtained from normal pregnant women who delivered at term or underwent elective pregnancy termination at 6 to 23 + 6 weeks of pregnancy. Placental tissues were analyzed for total antioxidant capacity (TAC) and lipid peroxide (malondialdehyde, MDA) levels using commercially available kits. Two hundred and one placental tissues were analyzed and the mean ± SD MDA (pmol/mg tissue) and TAC (µmol Trolox equivalent/mg tissue) levels for first, second, and third trimester groups were 277.01 ± 204.66, 202.66 ± 185.05, and 176.97 ± 141.61, P < 0.004 and 498.62 ± 400.74, 454.90 ± 374.44, and 912.19 ± 586.21, P < 0.0001 by ANOVA, respectively. Our data reflects an increased oxidative stress in the placenta in the early phase of normal pregnancy. As pregnancy progressed, placental antioxidant protective mechanisms increased and lipid peroxidation markers decreased resulting in diminution in oxidative stress. Our findings provide a biochemical support to the concept of a hypoxic environment in early pregnancy. A decrease in placental oxidative stress in the second and third trimesters appears to be a physiological phenomenon of normal pregnancy. Deviations from this physiological phenomenon may result in placental-mediated disorders. |
| format | Article |
| id | doaj-art-8c9453fcd2e54c43af70a8ce5c920c22 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-8c9453fcd2e54c43af70a8ce5c920c222025-02-03T06:00:16ZengWileyObstetrics and Gynecology International1687-95891687-95972015-01-01201510.1155/2015/276095276095Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated PregnanciesJayasri Basu0Bolek Bendek1Enyonam Agamasu2Carolyn M. Salafia3Aruna Mishra4Nerys Benfield5Ronak Patel6Magdy Mikhail7Department of Obstetrics & Gynecology, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics & Gynecology, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics & Gynecology, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics & Gynecology, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics & Gynecology, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics & Gynecology, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics & Gynecology, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USADepartment of Obstetrics & Gynecology, Bronx Lebanon Hospital Center, 1650 Grand Concourse, Bronx, NY 10457, USAThe effects of gestational age on placental oxidative balance throughout gestation were investigated in women with uncomplicated pregnancies. Placental tissues were obtained from normal pregnant women who delivered at term or underwent elective pregnancy termination at 6 to 23 + 6 weeks of pregnancy. Placental tissues were analyzed for total antioxidant capacity (TAC) and lipid peroxide (malondialdehyde, MDA) levels using commercially available kits. Two hundred and one placental tissues were analyzed and the mean ± SD MDA (pmol/mg tissue) and TAC (µmol Trolox equivalent/mg tissue) levels for first, second, and third trimester groups were 277.01 ± 204.66, 202.66 ± 185.05, and 176.97 ± 141.61, P < 0.004 and 498.62 ± 400.74, 454.90 ± 374.44, and 912.19 ± 586.21, P < 0.0001 by ANOVA, respectively. Our data reflects an increased oxidative stress in the placenta in the early phase of normal pregnancy. As pregnancy progressed, placental antioxidant protective mechanisms increased and lipid peroxidation markers decreased resulting in diminution in oxidative stress. Our findings provide a biochemical support to the concept of a hypoxic environment in early pregnancy. A decrease in placental oxidative stress in the second and third trimesters appears to be a physiological phenomenon of normal pregnancy. Deviations from this physiological phenomenon may result in placental-mediated disorders.http://dx.doi.org/10.1155/2015/276095 |
| spellingShingle | Jayasri Basu Bolek Bendek Enyonam Agamasu Carolyn M. Salafia Aruna Mishra Nerys Benfield Ronak Patel Magdy Mikhail Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies Obstetrics and Gynecology International |
| title | Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies |
| title_full | Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies |
| title_fullStr | Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies |
| title_full_unstemmed | Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies |
| title_short | Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies |
| title_sort | placental oxidative status throughout normal gestation in women with uncomplicated pregnancies |
| url | http://dx.doi.org/10.1155/2015/276095 |
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