Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia
T-lymphoblastic leukemia/lymphoma (T-ALL) presenting as blast phase of chronic myelogenous leukemia (CML-BP) is rare. In patients without history of CML, it is difficult to differentiate between CML-BP or de novo T-ALL. Here we reported 2 unusual cases of T-ALL presenting as CML-BP. Case 1 was a 24-...
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Wiley
2014-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2014/304359 |
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| author | Jie Xu Shaoying Li |
| author_facet | Jie Xu Shaoying Li |
| author_sort | Jie Xu |
| collection | DOAJ |
| description | T-lymphoblastic leukemia/lymphoma (T-ALL) presenting as blast phase of chronic myelogenous leukemia (CML-BP) is rare. In patients without history of CML, it is difficult to differentiate between CML-BP or de novo T-ALL. Here we reported 2 unusual cases of T-ALL presenting as CML-BP. Case 1 was a 24-year-old female with leukocytosis. Besides T-lymphoblasts (32%), her marrow exhibited some morphologic features of CML. Multiple remission or relapsing marrow had never demonstrated morphologic features of CML. Despite of imatinib treatment and stem cell transplant, she died 2.5 years later. Case 2, a 66-year-old male with diffuse lymphadenopathy, showed T-ALL in a lymph node and concurrent CML chronic phase (CML-CP) in his marrow. Same BCR-ABL1 fusion transcript with minor breakpoint was present in both the lymph node and marrow specimens. Although both cases did not have a history of CML, both cases represented T-lymphoblastic CML-BP with unusual features: Case 1 is unusual in that it presented as T-ALL with some CML morphologic feature but never showed CML-CP in her subsequent marrows biopsies; Case 2 is the first reported case of T-lymphoblastic CML-BP harboring BCR-ABL1 transcript with a minor breakpoint. |
| format | Article |
| id | doaj-art-8c92c75193db48a892b33d7fa59d8365 |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-8c92c75193db48a892b33d7fa59d83652025-08-20T02:09:33ZengWileyCase Reports in Hematology2090-65602090-65792014-01-01201410.1155/2014/304359304359Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous LeukemiaJie Xu0Shaoying Li1Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USADepartment of Pathology, Microbiology, and Immunology, School of Medicine, Vanderbilt University, 4605 TVC, Nashville, TN 37232-5310, USAT-lymphoblastic leukemia/lymphoma (T-ALL) presenting as blast phase of chronic myelogenous leukemia (CML-BP) is rare. In patients without history of CML, it is difficult to differentiate between CML-BP or de novo T-ALL. Here we reported 2 unusual cases of T-ALL presenting as CML-BP. Case 1 was a 24-year-old female with leukocytosis. Besides T-lymphoblasts (32%), her marrow exhibited some morphologic features of CML. Multiple remission or relapsing marrow had never demonstrated morphologic features of CML. Despite of imatinib treatment and stem cell transplant, she died 2.5 years later. Case 2, a 66-year-old male with diffuse lymphadenopathy, showed T-ALL in a lymph node and concurrent CML chronic phase (CML-CP) in his marrow. Same BCR-ABL1 fusion transcript with minor breakpoint was present in both the lymph node and marrow specimens. Although both cases did not have a history of CML, both cases represented T-lymphoblastic CML-BP with unusual features: Case 1 is unusual in that it presented as T-ALL with some CML morphologic feature but never showed CML-CP in her subsequent marrows biopsies; Case 2 is the first reported case of T-lymphoblastic CML-BP harboring BCR-ABL1 transcript with a minor breakpoint.http://dx.doi.org/10.1155/2014/304359 |
| spellingShingle | Jie Xu Shaoying Li Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia Case Reports in Hematology |
| title | Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia |
| title_full | Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia |
| title_fullStr | Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia |
| title_full_unstemmed | Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia |
| title_short | Unusual T-Lymphoblastic Blast Phase of Chronic Myelogenous Leukemia |
| title_sort | unusual t lymphoblastic blast phase of chronic myelogenous leukemia |
| url | http://dx.doi.org/10.1155/2014/304359 |
| work_keys_str_mv | AT jiexu unusualtlymphoblasticblastphaseofchronicmyelogenousleukemia AT shaoyingli unusualtlymphoblasticblastphaseofchronicmyelogenousleukemia |