Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions
BackgroundLung organoids have emerged as a promising tool for studying lung development, function, and disease pathology. The present study aimed to analyze the current status and development trends of lung organoid research over the past years, present visual representations, and provide references...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1611304/full |
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| author | Qian Wang Shiyan Tan Xi Fu Xi Fu Jiawei He Qiong Ma Fengming You Fengming You Liting You Yifeng Ren Yifeng Ren |
| author_facet | Qian Wang Shiyan Tan Xi Fu Xi Fu Jiawei He Qiong Ma Fengming You Fengming You Liting You Yifeng Ren Yifeng Ren |
| author_sort | Qian Wang |
| collection | DOAJ |
| description | BackgroundLung organoids have emerged as a promising tool for studying lung development, function, and disease pathology. The present study aimed to analyze the current status and development trends of lung organoid research over the past years, present visual representations, and provide references for future research directions using bibliometric analysis.MethodsInformation on articles on lung organoids extracted from the Web of Science Core Collection, such as year of publication, journal, country, institution, author, and keywords, was analyzed. R, VOSviewer, and SCImago Graphica were used to visualize publication trends, co-authorship analysis, co-occurrence analysis, and hotspot evolution.ResultsThe number of global publications has increased from 1 in 2011 to 929 in 2024. The Nature produced the highest number of citations (2,675 citations). The United States (8,155 citations and 281 publications), University Medical Center Utrecht (2083 citations and 11 publications), and Clevers H (2,711 citations and 21 publications) were the most influential countries, institutions, and authors, respectively. Co-occurrence cluster analysis of the top 54 keywords formed four clusters: (1) idiopathic pulmonary fibrosis, (2) lung cancer, (3) cystic fibrosis, (4) COVID-19.ConclusionOverall, research on lung organoids continues to increase. The United States of America and the Netherlands dominated global studies. The analysis of pulmonary fibrosis, lung cancer and COVID-19 occupied a prominent position of research in this area. The research hotspots for lung organoids are disease model and microphysiological systems. Standardization, accurate disease modeling, and ethics and safety remain pressing challenges that need to be addressed in this field. |
| format | Article |
| id | doaj-art-8c90841c9a4e499b85e66bdaa004c93d |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-8c90841c9a4e499b85e66bdaa004c93d2025-08-20T03:13:32ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.16113041611304Advancing lung organoids toward clinical applications: a global perspective on research focus and future directionsQian Wang0Shiyan Tan1Xi Fu2Xi Fu3Jiawei He4Qiong Ma5Fengming You6Fengming You7Liting You8Yifeng Ren9Yifeng Ren10Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, ChinaHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaTCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaBackgroundLung organoids have emerged as a promising tool for studying lung development, function, and disease pathology. The present study aimed to analyze the current status and development trends of lung organoid research over the past years, present visual representations, and provide references for future research directions using bibliometric analysis.MethodsInformation on articles on lung organoids extracted from the Web of Science Core Collection, such as year of publication, journal, country, institution, author, and keywords, was analyzed. R, VOSviewer, and SCImago Graphica were used to visualize publication trends, co-authorship analysis, co-occurrence analysis, and hotspot evolution.ResultsThe number of global publications has increased from 1 in 2011 to 929 in 2024. The Nature produced the highest number of citations (2,675 citations). The United States (8,155 citations and 281 publications), University Medical Center Utrecht (2083 citations and 11 publications), and Clevers H (2,711 citations and 21 publications) were the most influential countries, institutions, and authors, respectively. Co-occurrence cluster analysis of the top 54 keywords formed four clusters: (1) idiopathic pulmonary fibrosis, (2) lung cancer, (3) cystic fibrosis, (4) COVID-19.ConclusionOverall, research on lung organoids continues to increase. The United States of America and the Netherlands dominated global studies. The analysis of pulmonary fibrosis, lung cancer and COVID-19 occupied a prominent position of research in this area. The research hotspots for lung organoids are disease model and microphysiological systems. Standardization, accurate disease modeling, and ethics and safety remain pressing challenges that need to be addressed in this field.https://www.frontiersin.org/articles/10.3389/fmed.2025.1611304/fulllung organoidsclinical applicationsresearch focusfuture directionsbibliometric |
| spellingShingle | Qian Wang Shiyan Tan Xi Fu Xi Fu Jiawei He Qiong Ma Fengming You Fengming You Liting You Yifeng Ren Yifeng Ren Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions Frontiers in Medicine lung organoids clinical applications research focus future directions bibliometric |
| title | Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions |
| title_full | Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions |
| title_fullStr | Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions |
| title_full_unstemmed | Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions |
| title_short | Advancing lung organoids toward clinical applications: a global perspective on research focus and future directions |
| title_sort | advancing lung organoids toward clinical applications a global perspective on research focus and future directions |
| topic | lung organoids clinical applications research focus future directions bibliometric |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1611304/full |
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