Pharmacological inhibition of receptor protein tyrosine phosphatase β/ζ decreases Aβ plaques and neuroinflammation in the hippocampus of APP/PS1 mice

Pharmacological inhibition of receptor protein tyrosine phosphatase β/ζ decreases Aβ plaques and neuroinflammation in the hippocampus of APP/PS1 mice

Alzheimer’s disease (AD) is a major neurodegenerative disorder that courses with chronic neuroinflammation. Pleiotrophin (PTN) is an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ which is upregulated in different neuroinflammatory disorders of diverse origin, including AD....

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Main Authors: Teresa Fontán-Baselga, Héctor Cañeque-Rufo, Elisa Rivera-Illades, Esther Gramage, José María Zapico, Beatriz de Pascual-Teresa, María Del Pilar Ramos-Álvarez, Gonzalo Herradón, Marta Vicente-Rodríguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
RPTP β/ζ
MY10
pleiotrophin
neuroinflammation
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1506049/full
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