Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature
ABSTRACT Background and Aims Chronic Spontaneous Urticaria is characterized by the sudden onset of itchy wheals and angioedema and is primarily driven by mast cells. It can have a significant impact on the Quality of Life (QoL) of an individual. While the role of mast cells in urticaria is extensive...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70777 |
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| author | Asad Ullah Wasim Sri Anugna Miriyala Raymond Haward Zeinab Hammoud Pratik Agarwal Nirja Kaka Neil Patel Yashendra Sethi Poonam Gupta |
| author_facet | Asad Ullah Wasim Sri Anugna Miriyala Raymond Haward Zeinab Hammoud Pratik Agarwal Nirja Kaka Neil Patel Yashendra Sethi Poonam Gupta |
| author_sort | Asad Ullah Wasim |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Chronic Spontaneous Urticaria is characterized by the sudden onset of itchy wheals and angioedema and is primarily driven by mast cells. It can have a significant impact on the Quality of Life (QoL) of an individual. While the role of mast cells in urticaria is extensively described, the link between sleep disorders and inflammatory skin conditions such as urticaria is still being explored. The review aims to provide an overview of the current knowledge about chronic urticaria, elaborating on the impact of poor sleep quality on QoL of patients with urticaria, with a focus on their emotional well‐being. Methods The review explores potential mechanisms linking chronic urticaria and sleep disturbances, such as persistent itching and discomfort, the release of inflammatory mediators, systemic inflammation, psychological factors, and effects of medication. Results The review finds that sleep disturbances have a significant impact on chronic urticaria. It identifies several potential mechanisms linking the two conditions, including persistent symptoms, inflammatory processes, psychological factors, and medication effects. Treatment approaches include a combination of pharmacological and nonpharmacological interventions. Conclusion The article emphasizes the significance of recognizing the impact of sleep disturbances on chronic urticaria. It lays the groundwork for future research to expand our understanding of this association, ultimately leading to improved management strategies and improved QoL for affected individuals. |
| format | Article |
| id | doaj-art-8c8d02a3a985402da92cfa6366eb2250 |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-8c8d02a3a985402da92cfa6366eb22502025-08-20T03:59:36ZengWileyHealth Science Reports2398-88352025-05-0185n/an/a10.1002/hsr2.70777Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving LiteratureAsad Ullah Wasim0Sri Anugna Miriyala1Raymond Haward2Zeinab Hammoud3Pratik Agarwal4Nirja Kaka5Neil Patel6Yashendra Sethi7Poonam Gupta8Fazaia Medical College Islamabad PakistanKamineni Institute of Medical Sciences Varkatpally IndiaVydehi Institute of Medical Sciences and Research Centre Bengaluru IndiaFaculty of Medical Sciences Lebanese University Beirut LebanonPearResearch Dehradun IndiaPearResearch Dehradun IndiaPearResearch Dehradun IndiaPearResearch Dehradun IndiaMoti Lal Nehru Medical College Prayagraj Uttar Pradesh IndiaABSTRACT Background and Aims Chronic Spontaneous Urticaria is characterized by the sudden onset of itchy wheals and angioedema and is primarily driven by mast cells. It can have a significant impact on the Quality of Life (QoL) of an individual. While the role of mast cells in urticaria is extensively described, the link between sleep disorders and inflammatory skin conditions such as urticaria is still being explored. The review aims to provide an overview of the current knowledge about chronic urticaria, elaborating on the impact of poor sleep quality on QoL of patients with urticaria, with a focus on their emotional well‐being. Methods The review explores potential mechanisms linking chronic urticaria and sleep disturbances, such as persistent itching and discomfort, the release of inflammatory mediators, systemic inflammation, psychological factors, and effects of medication. Results The review finds that sleep disturbances have a significant impact on chronic urticaria. It identifies several potential mechanisms linking the two conditions, including persistent symptoms, inflammatory processes, psychological factors, and medication effects. Treatment approaches include a combination of pharmacological and nonpharmacological interventions. Conclusion The article emphasizes the significance of recognizing the impact of sleep disturbances on chronic urticaria. It lays the groundwork for future research to expand our understanding of this association, ultimately leading to improved management strategies and improved QoL for affected individuals.https://doi.org/10.1002/hsr2.70777CSUsleepsleep qualityurticaria |
| spellingShingle | Asad Ullah Wasim Sri Anugna Miriyala Raymond Haward Zeinab Hammoud Pratik Agarwal Nirja Kaka Neil Patel Yashendra Sethi Poonam Gupta Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature Health Science Reports CSU sleep sleep quality urticaria |
| title | Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature |
| title_full | Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature |
| title_fullStr | Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature |
| title_full_unstemmed | Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature |
| title_short | Sleep Disturbance and Chronic Urticaria: A Narrative Review of Its Relationship, Treatment and Evolving Literature |
| title_sort | sleep disturbance and chronic urticaria a narrative review of its relationship treatment and evolving literature |
| topic | CSU sleep sleep quality urticaria |
| url | https://doi.org/10.1002/hsr2.70777 |
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