Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives

Phaleria macrocarpa, a medicinal plant from the Thymelaceae family, is predominantly found in Malaysia and Indonesia. This review aims to comprehensively summarize the phytochemical, pharmacological, and toxicological aspects of P. macrocarpa, along with modern approaches and safety concerns. Data...

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Main Authors: Anandarajagopal Kalusalingam, Kamaliah Kamal, Abdullah Khan, Bama Menon, Ching Siang Tan, Venkateshan Narayanan, Sattanathan Kumar, Khang Wen Goh, Kah Seng Lee, Jactty Chew, Long Chiau Ming
Format: Article
Language:English
Published: HH Publisher 2024-11-01
Series:Progress in Microbes and Molecular Biology
Online Access:https://journals.hh-publisher.com/index.php/pmmb/article/view/1080
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author Anandarajagopal Kalusalingam
Kamaliah Kamal
Abdullah Khan
Bama Menon
Ching Siang Tan
Venkateshan Narayanan
Sattanathan Kumar
Khang Wen Goh
Kah Seng Lee
Jactty Chew
Long Chiau Ming
author_facet Anandarajagopal Kalusalingam
Kamaliah Kamal
Abdullah Khan
Bama Menon
Ching Siang Tan
Venkateshan Narayanan
Sattanathan Kumar
Khang Wen Goh
Kah Seng Lee
Jactty Chew
Long Chiau Ming
author_sort Anandarajagopal Kalusalingam
collection DOAJ
description Phaleria macrocarpa, a medicinal plant from the Thymelaceae family, is predominantly found in Malaysia and Indonesia. This review aims to comprehensively summarize the phytochemical, pharmacological, and toxicological aspects of P. macrocarpa, along with modern approaches and safety concerns. Data for the review were collected from various scientific databases and relevant literature on P. macrocarpa. The review discusses the plant's phytochemical composition and its diverse medicinal properties, including anti-inflammatory, antihypertensive, antidiabetic, antioxidant, antimicrobial, antipyretic, antiulcer, antiviral and anticancer activities. P. macrocarpa has also been used to treat various female health conditions. Additionally, combination therapies and advanced drug delivery systems such as nanoemulsion have been reviewed. These pharmacological activities are attributed to the plant's phytoconstituents. The review will be valuable for researchers involved in medicinal plant research and drug discovery, offering potential for use alongside modern therapeutic agents. However, clinical studies are essential to validate its therapeutic applications. Further research is required to develop standardized herbal pharmaceuticals from P. macrocarpa that are effective, safe, and meet regulatory standards for quality assurance.
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institution Kabale University
issn 2637-1049
language English
publishDate 2024-11-01
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spelling doaj-art-8c8c2de52c544d60af51da540b6d4b0f2025-02-04T08:39:35ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492024-11-017110.36877/pmmb.a0000452Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development PerspectivesAnandarajagopal KalusalingamKamaliah KamalAbdullah KhanBama MenonChing Siang TanVenkateshan NarayananSattanathan KumarKhang Wen GohKah Seng LeeJactty ChewLong Chiau Ming Phaleria macrocarpa, a medicinal plant from the Thymelaceae family, is predominantly found in Malaysia and Indonesia. This review aims to comprehensively summarize the phytochemical, pharmacological, and toxicological aspects of P. macrocarpa, along with modern approaches and safety concerns. Data for the review were collected from various scientific databases and relevant literature on P. macrocarpa. The review discusses the plant's phytochemical composition and its diverse medicinal properties, including anti-inflammatory, antihypertensive, antidiabetic, antioxidant, antimicrobial, antipyretic, antiulcer, antiviral and anticancer activities. P. macrocarpa has also been used to treat various female health conditions. Additionally, combination therapies and advanced drug delivery systems such as nanoemulsion have been reviewed. These pharmacological activities are attributed to the plant's phytoconstituents. The review will be valuable for researchers involved in medicinal plant research and drug discovery, offering potential for use alongside modern therapeutic agents. However, clinical studies are essential to validate its therapeutic applications. Further research is required to develop standardized herbal pharmaceuticals from P. macrocarpa that are effective, safe, and meet regulatory standards for quality assurance. https://journals.hh-publisher.com/index.php/pmmb/article/view/1080
spellingShingle Anandarajagopal Kalusalingam
Kamaliah Kamal
Abdullah Khan
Bama Menon
Ching Siang Tan
Venkateshan Narayanan
Sattanathan Kumar
Khang Wen Goh
Kah Seng Lee
Jactty Chew
Long Chiau Ming
Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives
Progress in Microbes and Molecular Biology
title Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives
title_full Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives
title_fullStr Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives
title_full_unstemmed Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives
title_short Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives
title_sort phaleria macrocarpa scheff boerl in ethnopharmacology pharmacognosy safety and drug development perspectives
url https://journals.hh-publisher.com/index.php/pmmb/article/view/1080
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