Triage of women with a positive HPV DNA test: evaluating a DNA methylation panel for detecting cervical intraepithelial neoplasia grade 3 and cervical cancer in cervical cytology samples

Triage of women with a positive HPV DNA test: evaluating a DNA methylation panel for detecting cervical intraepithelial neoplasia grade 3 and cervical cancer in cervical cytology samples

Abstract Background Efficient triage of high-risk human papillomavirus (hrHPV)-positive women is essential to avoid unnecessary referrals and overtreatment. This study evaluates the diagnostic accuracy of the commercially available DNA methylation panel, GynTect® (ASTN1, DLX1, ITGA4, RXFP3, SOX17, a...

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Bibliographic Details
Main Authors: Yifei Ren, Fengjiang Qin, Li Shen, LanFang Li, Qingrong Wu, Ping Yi
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Cancer
Subjects:
Cervical cancer
CIN
DNA methylation
GynTect® test
High-risk human papillomavirus
Triage
Online Access:https://doi.org/10.1186/s12885-025-14531-z
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