Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome
Abstract Background To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome. Methods Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-04-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
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| Online Access: | https://doi.org/10.1186/s40463-023-00627-8 |
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| author | Lukas Anschuetz Ralph Hohenberger Christoph Kaecker Olgun Elicin Roland Giger Marco Caversaccio |
| author_facet | Lukas Anschuetz Ralph Hohenberger Christoph Kaecker Olgun Elicin Roland Giger Marco Caversaccio |
| author_sort | Lukas Anschuetz |
| collection | DOAJ |
| description | Abstract Background To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome. Methods Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008 and 2019. A chart review on patient and tumor characteristics, treatment and long-term outcome was performed. Results Most frequent histological types were squamous cell carcinoma (SCC) (n = 74), adenocarcinoma (n = 24) and mucosal melanoma (n = 18). Primary therapy was surgery in 66% of patients (n = 95) of which 65.8% (n = 66) received adjuvant radiotherapy. Twenty patients (13.8%) were initially staged as cN + and in seven cases, pN + status was histopathologically confirmed. Fifty-six of 130 patients (43.1%) had a relapse after curative intended therapy, including nine loco-regional (6.9%) and seven isolated regional recurrences (5.4%). Twelve of these 16 patients with (loco-)regional recurrence had SCC. Adenoid cystic carcinoma (87.5%) and SCC (65.3%) showed the best long-term overall survival. Conclusions Regional involvement and regional recurrence are scarce. Because of rarity and heterogeneity, evidence on therapeutic management is sparse resulting in the lack of clinical guidelines. Graphical Abstract |
| format | Article |
| id | doaj-art-8c88a4d1dd7c4b1db5bcb43a75a7a17c |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-8c88a4d1dd7c4b1db5bcb43a75a7a17c2025-02-03T11:13:51ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162023-04-015211910.1186/s40463-023-00627-8Sinonasal malignancies: histopathological entities, regional involvement and long-term outcomeLukas Anschuetz0Ralph Hohenberger1Christoph Kaecker2Olgun Elicin3Roland Giger4Marco Caversaccio5Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of BernDepartment of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of BernDepartment of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of BernDepartment of Radiation Oncology, Inselspital, Bern University Hospital, University of BernDepartment of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of BernDepartment of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of BernAbstract Background To assess a large patient cohort with sinonasal malignancies focusing on regional involvement, recurrence and oncological outcome. Methods Patients (n = 144) with malignant tumors of the nasal cavity and paranasal sinuses were treated at our tertiary referral center between 2008 and 2019. A chart review on patient and tumor characteristics, treatment and long-term outcome was performed. Results Most frequent histological types were squamous cell carcinoma (SCC) (n = 74), adenocarcinoma (n = 24) and mucosal melanoma (n = 18). Primary therapy was surgery in 66% of patients (n = 95) of which 65.8% (n = 66) received adjuvant radiotherapy. Twenty patients (13.8%) were initially staged as cN + and in seven cases, pN + status was histopathologically confirmed. Fifty-six of 130 patients (43.1%) had a relapse after curative intended therapy, including nine loco-regional (6.9%) and seven isolated regional recurrences (5.4%). Twelve of these 16 patients with (loco-)regional recurrence had SCC. Adenoid cystic carcinoma (87.5%) and SCC (65.3%) showed the best long-term overall survival. Conclusions Regional involvement and regional recurrence are scarce. Because of rarity and heterogeneity, evidence on therapeutic management is sparse resulting in the lack of clinical guidelines. Graphical Abstracthttps://doi.org/10.1186/s40463-023-00627-8Nasal cancerMucosal melanomaSquamous cell carcinomaRegional recurrenceRare cancer |
| spellingShingle | Lukas Anschuetz Ralph Hohenberger Christoph Kaecker Olgun Elicin Roland Giger Marco Caversaccio Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome Journal of Otolaryngology - Head and Neck Surgery Nasal cancer Mucosal melanoma Squamous cell carcinoma Regional recurrence Rare cancer |
| title | Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome |
| title_full | Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome |
| title_fullStr | Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome |
| title_full_unstemmed | Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome |
| title_short | Sinonasal malignancies: histopathological entities, regional involvement and long-term outcome |
| title_sort | sinonasal malignancies histopathological entities regional involvement and long term outcome |
| topic | Nasal cancer Mucosal melanoma Squamous cell carcinoma Regional recurrence Rare cancer |
| url | https://doi.org/10.1186/s40463-023-00627-8 |
| work_keys_str_mv | AT lukasanschuetz sinonasalmalignancieshistopathologicalentitiesregionalinvolvementandlongtermoutcome AT ralphhohenberger sinonasalmalignancieshistopathologicalentitiesregionalinvolvementandlongtermoutcome AT christophkaecker sinonasalmalignancieshistopathologicalentitiesregionalinvolvementandlongtermoutcome AT olgunelicin sinonasalmalignancieshistopathologicalentitiesregionalinvolvementandlongtermoutcome AT rolandgiger sinonasalmalignancieshistopathologicalentitiesregionalinvolvementandlongtermoutcome AT marcocaversaccio sinonasalmalignancieshistopathologicalentitiesregionalinvolvementandlongtermoutcome |