The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment Response
MR enterography (MRE) has become the primary imaging modality in the assessment of Crohn’s disease (CD) in both children and adults at many institutions in the United States and worldwide, primarily due to its noninvasiveness, superior soft tissue contrast, and lack of ionizing radiation. MRE techni...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/8168695 |
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| author | Matthew P. Moy Jenny Sauk Michael S. Gee |
| author_facet | Matthew P. Moy Jenny Sauk Michael S. Gee |
| author_sort | Matthew P. Moy |
| collection | DOAJ |
| description | MR enterography (MRE) has become the primary imaging modality in the assessment of Crohn’s disease (CD) in both children and adults at many institutions in the United States and worldwide, primarily due to its noninvasiveness, superior soft tissue contrast, and lack of ionizing radiation. MRE technique includes distention of the small bowel with oral contrast media with the acquisition of T2-weighted, balanced steady-state free precession, and multiphase T1-weighted fat suppressed gadolinium contrast-enhanced sequences. With the introduction of molecule-targeted biologic agents into the clinical setting for CD and their potential to reverse the inflammatory process, MRE is increasingly utilized to evaluate disease activity and response to therapy as an imaging complement to clinical indices or optical endoscopy. New and emerging MRE techniques, such as diffusion-weighted imaging (DWI), magnetization transfer, ultrasmall superparamagnetic iron oxide- (USPIO-) enhanced MRI, and PET-MR, offer the potential for an expanded role of MRI in detecting occult disease activity, evaluating early treatment response/resistance, and differentiating inflammatory from fibrotic strictures. Familiarity with MR enterography is essential for radiologists and gastroenterologists as the technique evolves and is further incorporated into the clinical management of CD. |
| format | Article |
| id | doaj-art-8c83d911cdbd40a39153796b28d34da6 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Gastroenterology Research and Practice |
| spelling | doaj-art-8c83d911cdbd40a39153796b28d34da62025-02-03T05:50:50ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/81686958168695The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment ResponseMatthew P. Moy0Jenny Sauk1Michael S. Gee2Division of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USADivision of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USADivision of Abdominal Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USAMR enterography (MRE) has become the primary imaging modality in the assessment of Crohn’s disease (CD) in both children and adults at many institutions in the United States and worldwide, primarily due to its noninvasiveness, superior soft tissue contrast, and lack of ionizing radiation. MRE technique includes distention of the small bowel with oral contrast media with the acquisition of T2-weighted, balanced steady-state free precession, and multiphase T1-weighted fat suppressed gadolinium contrast-enhanced sequences. With the introduction of molecule-targeted biologic agents into the clinical setting for CD and their potential to reverse the inflammatory process, MRE is increasingly utilized to evaluate disease activity and response to therapy as an imaging complement to clinical indices or optical endoscopy. New and emerging MRE techniques, such as diffusion-weighted imaging (DWI), magnetization transfer, ultrasmall superparamagnetic iron oxide- (USPIO-) enhanced MRI, and PET-MR, offer the potential for an expanded role of MRI in detecting occult disease activity, evaluating early treatment response/resistance, and differentiating inflammatory from fibrotic strictures. Familiarity with MR enterography is essential for radiologists and gastroenterologists as the technique evolves and is further incorporated into the clinical management of CD.http://dx.doi.org/10.1155/2016/8168695 |
| spellingShingle | Matthew P. Moy Jenny Sauk Michael S. Gee The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment Response Gastroenterology Research and Practice |
| title | The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment Response |
| title_full | The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment Response |
| title_fullStr | The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment Response |
| title_full_unstemmed | The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment Response |
| title_short | The Role of MR Enterography in Assessing Crohn’s Disease Activity and Treatment Response |
| title_sort | role of mr enterography in assessing crohn s disease activity and treatment response |
| url | http://dx.doi.org/10.1155/2016/8168695 |
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