Neuroinflammation-mediated YKL-40 correlates with tau pathology and predicts longitudinal cognitive impairment and brain atrophy in Alzheimer’s disease, with hypertensive dependency

Neuroinflammation-mediated YKL-40 correlates with tau pathology and predicts longitudinal cognitive impairment and brain atrophy in Alzheimer’s disease, with hypertensive dependency

BackgroundNeuroinflammation and hypertension are involved in Alzheimer’s disease (AD). However, their independent and additive impacts on astrocytes and AD-related pathologies have not been fully explored. Hence, this study investigated whether the associations between astrocyte reactivity, measured...

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Main Authors: Ya-Yu Wang, Man Zhang, Shu-Jian Chen, Wei Miao, Zhi-Xin Wang, Ya-Jun Zhou, Si-Qi Yu, Zhong-Wu Sun, Xia Zhou, Xian-Feng Yu, Xiao-Qun Zhu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
astrocyte reactivity
YKL-40
neuroinflammation
hypertension
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1630022/full
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