Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer
Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thous...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/8856326 |
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| author | Zi-hang Xu Yang-zhuangzhuang Zhu Lin Su Xue-yang Tang Chao Yao Xiao-ning Jiao Yi-fei Hou Xiao Chen Lu-yao Wei Wan-tao Wang Jie Wang Chen-yuan Gong Xian-dan Zhu Fei Zhang Shi-guo Zhu Chun-pu Zou |
| author_facet | Zi-hang Xu Yang-zhuangzhuang Zhu Lin Su Xue-yang Tang Chao Yao Xiao-ning Jiao Yi-fei Hou Xiao Chen Lu-yao Wei Wan-tao Wang Jie Wang Chen-yuan Gong Xian-dan Zhu Fei Zhang Shi-guo Zhu Chun-pu Zou |
| author_sort | Zi-hang Xu |
| collection | DOAJ |
| description | Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thousands of years, could directly inhibit the growth of human NSCLC cells via the p53 signaling pathway. In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment (TME). ZQT remarkably reduced the number of MDSCs (especially G-MDSCs) and inhibited their immunosuppressive activity by inducing apoptosis in these cells via the STAT3/S100A9/Bcl-2/caspase-3 signaling pathway. When G-MDSCs were depleted, the survival promotion effect of ZQT and its inhibitory effect on lung luminescence signal disappeared in tumor-bearing mice. This is the first study to illustrate the immunomodulatory effect of ZQT in NSCLC and the underlying molecular mechanism. |
| format | Article |
| id | doaj-art-8c7d65eac78843dfa960c941bbbd5f88 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8c7d65eac78843dfa960c941bbbd5f882025-08-20T03:37:46ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/88563268856326Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung CancerZi-hang Xu0Yang-zhuangzhuang Zhu1Lin Su2Xue-yang Tang3Chao Yao4Xiao-ning Jiao5Yi-fei Hou6Xiao Chen7Lu-yao Wei8Wan-tao Wang9Jie Wang10Chen-yuan Gong11Xian-dan Zhu12Fei Zhang13Shi-guo Zhu14Chun-pu Zou15School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaCenter of Technology Experiment, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaDepartment of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaNon-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thousands of years, could directly inhibit the growth of human NSCLC cells via the p53 signaling pathway. In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment (TME). ZQT remarkably reduced the number of MDSCs (especially G-MDSCs) and inhibited their immunosuppressive activity by inducing apoptosis in these cells via the STAT3/S100A9/Bcl-2/caspase-3 signaling pathway. When G-MDSCs were depleted, the survival promotion effect of ZQT and its inhibitory effect on lung luminescence signal disappeared in tumor-bearing mice. This is the first study to illustrate the immunomodulatory effect of ZQT in NSCLC and the underlying molecular mechanism.http://dx.doi.org/10.1155/2021/8856326 |
| spellingShingle | Zi-hang Xu Yang-zhuangzhuang Zhu Lin Su Xue-yang Tang Chao Yao Xiao-ning Jiao Yi-fei Hou Xiao Chen Lu-yao Wei Wan-tao Wang Jie Wang Chen-yuan Gong Xian-dan Zhu Fei Zhang Shi-guo Zhu Chun-pu Zou Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer Mediators of Inflammation |
| title | Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer |
| title_full | Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer |
| title_fullStr | Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer |
| title_full_unstemmed | Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer |
| title_short | Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer |
| title_sort | ze qi tang formula induces granulocytic myeloid derived suppressor cell apoptosis via stat3 s100a9 bcl 2 caspase 3 signaling to prolong the survival of mice with orthotopic lung cancer |
| url | http://dx.doi.org/10.1155/2021/8856326 |
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