Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer

Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thous...

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Main Authors: Zi-hang Xu, Yang-zhuangzhuang Zhu, Lin Su, Xue-yang Tang, Chao Yao, Xiao-ning Jiao, Yi-fei Hou, Xiao Chen, Lu-yao Wei, Wan-tao Wang, Jie Wang, Chen-yuan Gong, Xian-dan Zhu, Fei Zhang, Shi-guo Zhu, Chun-pu Zou
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2021/8856326
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author Zi-hang Xu
Yang-zhuangzhuang Zhu
Lin Su
Xue-yang Tang
Chao Yao
Xiao-ning Jiao
Yi-fei Hou
Xiao Chen
Lu-yao Wei
Wan-tao Wang
Jie Wang
Chen-yuan Gong
Xian-dan Zhu
Fei Zhang
Shi-guo Zhu
Chun-pu Zou
author_facet Zi-hang Xu
Yang-zhuangzhuang Zhu
Lin Su
Xue-yang Tang
Chao Yao
Xiao-ning Jiao
Yi-fei Hou
Xiao Chen
Lu-yao Wei
Wan-tao Wang
Jie Wang
Chen-yuan Gong
Xian-dan Zhu
Fei Zhang
Shi-guo Zhu
Chun-pu Zou
author_sort Zi-hang Xu
collection DOAJ
description Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thousands of years, could directly inhibit the growth of human NSCLC cells via the p53 signaling pathway. In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment (TME). ZQT remarkably reduced the number of MDSCs (especially G-MDSCs) and inhibited their immunosuppressive activity by inducing apoptosis in these cells via the STAT3/S100A9/Bcl-2/caspase-3 signaling pathway. When G-MDSCs were depleted, the survival promotion effect of ZQT and its inhibitory effect on lung luminescence signal disappeared in tumor-bearing mice. This is the first study to illustrate the immunomodulatory effect of ZQT in NSCLC and the underlying molecular mechanism.
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publishDate 2021-01-01
publisher Wiley
record_format Article
series Mediators of Inflammation
spelling doaj-art-8c7d65eac78843dfa960c941bbbd5f882025-08-20T03:37:46ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/88563268856326Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung CancerZi-hang Xu0Yang-zhuangzhuang Zhu1Lin Su2Xue-yang Tang3Chao Yao4Xiao-ning Jiao5Yi-fei Hou6Xiao Chen7Lu-yao Wei8Wan-tao Wang9Jie Wang10Chen-yuan Gong11Xian-dan Zhu12Fei Zhang13Shi-guo Zhu14Chun-pu Zou15School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaCenter of Technology Experiment, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaDepartment of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai 200092, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaSchool of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, ChinaNon-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thousands of years, could directly inhibit the growth of human NSCLC cells via the p53 signaling pathway. In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment (TME). ZQT remarkably reduced the number of MDSCs (especially G-MDSCs) and inhibited their immunosuppressive activity by inducing apoptosis in these cells via the STAT3/S100A9/Bcl-2/caspase-3 signaling pathway. When G-MDSCs were depleted, the survival promotion effect of ZQT and its inhibitory effect on lung luminescence signal disappeared in tumor-bearing mice. This is the first study to illustrate the immunomodulatory effect of ZQT in NSCLC and the underlying molecular mechanism.http://dx.doi.org/10.1155/2021/8856326
spellingShingle Zi-hang Xu
Yang-zhuangzhuang Zhu
Lin Su
Xue-yang Tang
Chao Yao
Xiao-ning Jiao
Yi-fei Hou
Xiao Chen
Lu-yao Wei
Wan-tao Wang
Jie Wang
Chen-yuan Gong
Xian-dan Zhu
Fei Zhang
Shi-guo Zhu
Chun-pu Zou
Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer
Mediators of Inflammation
title Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer
title_full Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer
title_fullStr Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer
title_full_unstemmed Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer
title_short Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer
title_sort ze qi tang formula induces granulocytic myeloid derived suppressor cell apoptosis via stat3 s100a9 bcl 2 caspase 3 signaling to prolong the survival of mice with orthotopic lung cancer
url http://dx.doi.org/10.1155/2021/8856326
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