High-Intensity Statins Promote PCSK9 Secretion and aortic valve calcification in patients with severe aortic stenosis: In vitro and clinical evidence

High-Intensity Statins Promote PCSK9 Secretion and aortic valve calcification in patients with severe aortic stenosis: In vitro and clinical evidence

Aortic stenosis (AS) is the most common valvular disease, characterized by progressive fibro-calcific remodeling of the aortic leaflets, leading to increased morbidity and mortality. It is now well known that statins influence the production of proprotein convertase subtilisin/kexin type 9 (PCSK9),...

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Main Authors: Veronika A. Myasoedova, Matteo Franchi, Donato De Giorgi, Alice Bonomi, Vincenza Valerio, Sergio Pirola, Niccolò Andreani, Valentina Rusconi, Francesca Bertolini, Ilaria Massaiu, Gianluca Pontone, Paolo Poggio
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Pharmacological Research
Subjects:
Statin intensity
PCSK9
Aortic valve calcification
Aortic valve disease hospitalization
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825001628
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