Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects
The association between gut microbiota and circulating zonulin level, a marker of intestinal permeability, has not been studied yet. The aim of the study is the assessment of plasma zonulin, haptoglobin and proinflammatory cytokines (TNF-α and IL-6) levels in relation to composition of gut microbiot...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/674106 |
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| author | Agnieszka Żak-Gołąb Piotr Kocełak Małgorzata Aptekorz Maria Zientara Łukasz Juszczyk Gayane Martirosian Jerzy Chudek Magdalena Olszanecka-Glinianowicz |
| author_facet | Agnieszka Żak-Gołąb Piotr Kocełak Małgorzata Aptekorz Maria Zientara Łukasz Juszczyk Gayane Martirosian Jerzy Chudek Magdalena Olszanecka-Glinianowicz |
| author_sort | Agnieszka Żak-Gołąb |
| collection | DOAJ |
| description | The association between gut microbiota and circulating zonulin level, a marker of intestinal permeability, has not been studied yet. The aim of the study is the assessment of plasma zonulin, haptoglobin and proinflammatory cytokines (TNF-α and IL-6) levels in relation to composition of gut microbiota in obese and normal weight subjects. Circulating inflammation markers, such as TNF-α, sTNFR1, sTNFR2, IL-6, zonulin, and haptoglobin levels were measured and semiquantitative analysis of gut microbiota composition was carried out in 50 obese and 30 normal weight subjects without concomitant diseases. Higher circulating zonulin, TNF-α, sTNFR1, sTNFR2, and IL-6 levels were found in the obese subjects. Plasma zonulin level correlated positively with age (r=0.43, P<0.001), body mass (r=0.30, P<0.01), BMI (r=0.33, P<0.01), fat mass and fat percentage (r=0.31, P<0.01 and r=0.23, P<0.05, resp.). Positive correlations between bacterial colony count and sTNFR1 (r=0.33, P<0.01) and plasma zonulin (r=0.26, P<0.05) but not haptoglobin levels were found. Additionally, plasma zonulin level was proportional to daily energy intake (r=0.27, P<0.05) and serum glucose concentration (r=0.18, P<0.05) and inversely proportional to diet protein percentage (r=-0.23, P<0.05). Gut microbiota-related systemic microinflammation in the obese is reflected by circulating zonulin level, a potential marker of interstitial permeability. |
| format | Article |
| id | doaj-art-8c71284ee0ed4739a0ce910d5e7912bb |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8c71284ee0ed4739a0ce910d5e7912bb2025-02-03T05:54:21ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/674106674106Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight SubjectsAgnieszka Żak-Gołąb0Piotr Kocełak1Małgorzata Aptekorz2Maria Zientara3Łukasz Juszczyk4Gayane Martirosian5Jerzy Chudek6Magdalena Olszanecka-Glinianowicz7Pathophysiology Unit, Department of Pathophysiology, Medical University of Silesia, University of Silesia, 18 Medyków Street, 40-752 Katowice, PolandHealth Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, University of Silesia, 18 Medyków Street, 40-752 Katowice, PolandDepartment of Medical Microbiology, Medical University of Silesia, University of Silesia, 18 Medyków Street, 40-752 Katowice, PolandDepartment of Medical Microbiology, Medical University of Silesia, University of Silesia, 18 Medyków Street, 40-752 Katowice, PolandPathophysiology Unit, Department of Pathophysiology, Medical University of Silesia, University of Silesia, 18 Medyków Street, 40-752 Katowice, PolandDepartment of Medical Microbiology, Medical University of Silesia, University of Silesia, 18 Medyków Street, 40-752 Katowice, PolandPathophysiology Unit, Department of Pathophysiology, Medical University of Silesia, University of Silesia, 18 Medyków Street, 40-752 Katowice, PolandHealth Promotion and Obesity Management Unit, Department of Pathophysiology, Medical University of Silesia, University of Silesia, 18 Medyków Street, 40-752 Katowice, PolandThe association between gut microbiota and circulating zonulin level, a marker of intestinal permeability, has not been studied yet. The aim of the study is the assessment of plasma zonulin, haptoglobin and proinflammatory cytokines (TNF-α and IL-6) levels in relation to composition of gut microbiota in obese and normal weight subjects. Circulating inflammation markers, such as TNF-α, sTNFR1, sTNFR2, IL-6, zonulin, and haptoglobin levels were measured and semiquantitative analysis of gut microbiota composition was carried out in 50 obese and 30 normal weight subjects without concomitant diseases. Higher circulating zonulin, TNF-α, sTNFR1, sTNFR2, and IL-6 levels were found in the obese subjects. Plasma zonulin level correlated positively with age (r=0.43, P<0.001), body mass (r=0.30, P<0.01), BMI (r=0.33, P<0.01), fat mass and fat percentage (r=0.31, P<0.01 and r=0.23, P<0.05, resp.). Positive correlations between bacterial colony count and sTNFR1 (r=0.33, P<0.01) and plasma zonulin (r=0.26, P<0.05) but not haptoglobin levels were found. Additionally, plasma zonulin level was proportional to daily energy intake (r=0.27, P<0.05) and serum glucose concentration (r=0.18, P<0.05) and inversely proportional to diet protein percentage (r=-0.23, P<0.05). Gut microbiota-related systemic microinflammation in the obese is reflected by circulating zonulin level, a potential marker of interstitial permeability.http://dx.doi.org/10.1155/2013/674106 |
| spellingShingle | Agnieszka Żak-Gołąb Piotr Kocełak Małgorzata Aptekorz Maria Zientara Łukasz Juszczyk Gayane Martirosian Jerzy Chudek Magdalena Olszanecka-Glinianowicz Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects International Journal of Endocrinology |
| title | Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects |
| title_full | Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects |
| title_fullStr | Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects |
| title_full_unstemmed | Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects |
| title_short | Gut Microbiota, Microinflammation, Metabolic Profile, and Zonulin Concentration in Obese and Normal Weight Subjects |
| title_sort | gut microbiota microinflammation metabolic profile and zonulin concentration in obese and normal weight subjects |
| url | http://dx.doi.org/10.1155/2013/674106 |
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