PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients
Although the incidence of breast cancer in the United States is higher in Caucasian women compared with African American women, African-American patients have more aggressive disease as characterized by a higher percentage of triple-negative breast cancers (TNBCs), high-grade tumors, and a higher mo...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/740353 |
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| author | Debra A. Tonetti Weihua Gao Diana Escarzaga Kelly Walters April Szafran John S. Coon |
| author_facet | Debra A. Tonetti Weihua Gao Diana Escarzaga Kelly Walters April Szafran John S. Coon |
| author_sort | Debra A. Tonetti |
| collection | DOAJ |
| description | Although the incidence of breast cancer in the United States is higher in Caucasian women compared with African American women, African-American patients have more aggressive disease as characterized by a higher percentage of triple-negative breast cancers (TNBCs), high-grade tumors, and a higher mortality rate. PKCα is a biomarker associated with endocrine resistance and poor prognosis and ERβ is emerging as a protective biomarker. Immunohistochemical analysis of ERβ and PKCα expression was performed on 198 formalin-fixed paraffin-embedded primary infiltrating ductal carcinomas from 105 African-American and 93 Caucasian patients. PKCα is positively correlated with TNBC in patients of both races and with high tumor grade in African-American patients. Patients with TNBC express less nuclear ERβ compared with all other subtypes. We find no difference in frequency or intensity of PKCα or ERβ expression between African-American and Caucasian patients. PKCα and ERβ are discussed as potential therapeutic targets for the treatment of patients with TNBC. |
| format | Article |
| id | doaj-art-8c6cc445062f42dbabff77910f99d18d |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-8c6cc445062f42dbabff77910f99d18d2025-08-20T03:37:46ZengWileyInternational Journal of Breast Cancer2090-31702090-31892012-01-01201210.1155/2012/740353740353PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian PatientsDebra A. Tonetti0Weihua Gao1Diana Escarzaga2Kelly Walters3April Szafran4John S. Coon5Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, USADesign and Analysis Core, Center for Clinical and Translational Science, University of Illinois, 914 S. Wood Street, Chicago, IL 60612, USADepartment of Pathology, Rush University Medical Center, 1643 W. Congress Parkway, Murdock Building, Street 593, Chicago, IL 60612, USADepartment of Pathology, Rush University Medical Center, 1643 W. Congress Parkway, Murdock Building, Street 593, Chicago, IL 60612, USADepartment of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, IL 60612, USADepartment of Pathology, Rush University Medical Center, 1643 W. Congress Parkway, Murdock Building, Street 593, Chicago, IL 60612, USAAlthough the incidence of breast cancer in the United States is higher in Caucasian women compared with African American women, African-American patients have more aggressive disease as characterized by a higher percentage of triple-negative breast cancers (TNBCs), high-grade tumors, and a higher mortality rate. PKCα is a biomarker associated with endocrine resistance and poor prognosis and ERβ is emerging as a protective biomarker. Immunohistochemical analysis of ERβ and PKCα expression was performed on 198 formalin-fixed paraffin-embedded primary infiltrating ductal carcinomas from 105 African-American and 93 Caucasian patients. PKCα is positively correlated with TNBC in patients of both races and with high tumor grade in African-American patients. Patients with TNBC express less nuclear ERβ compared with all other subtypes. We find no difference in frequency or intensity of PKCα or ERβ expression between African-American and Caucasian patients. PKCα and ERβ are discussed as potential therapeutic targets for the treatment of patients with TNBC.http://dx.doi.org/10.1155/2012/740353 |
| spellingShingle | Debra A. Tonetti Weihua Gao Diana Escarzaga Kelly Walters April Szafran John S. Coon PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients International Journal of Breast Cancer |
| title | PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients |
| title_full | PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients |
| title_fullStr | PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients |
| title_full_unstemmed | PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients |
| title_short | PKCα and ERβ Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients |
| title_sort | pkcα and erβ are associated with triple negative breast cancers in african american and caucasian patients |
| url | http://dx.doi.org/10.1155/2012/740353 |
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