Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection

BackgroundAlzheimer’s disease (AD) requires early intervention at preclinical stages like subjective memory complaints (SMC). Traditional static brain network analyses lack sensitivity to detect early functional disruptions in SMC. This study aimed to improve preclinical AD stratification by integra...

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Bibliographic Details
Main Authors:	Juanjuan Jiang, Tao Kang, Ronghua Ling, Yingqian Liu, Jiuai Sun, Yiming Li, Xiaoou Li, Hui Yang, Bingcang Huang, the Alzheimer’s Disease Neuroimaging Initiative
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Aging Neuroscience
Subjects:	brain imaging dynamic network gray and white matter functional network Alzheimer’s disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1589018/full
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Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection

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