PIK3CA mutational status in tissue and plasma as a prognostic biomarker in HR+/HER2− breast cancer

PIK3CA mutational status in tissue and plasma as a prognostic biomarker in HR+/HER2− breast cancer

Abstract Introduction Hotspots (HS) mutations in the PIK3CA gene may lead to poorer oncological outcomes and endocrine resistance in advanced breast cancer (BC), but their prognostic role in early‐stage disease remains controversial. The overall agreement within plasma and tissue methods has not bee...

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Main Authors: Eduardo Terán, Rebeca Lozano, César A. Rodríguez, Mar Abad, Luis Figuero, José Antonio Muñoz, Belén Cigarral, Aline Rodrígues, Magdalena Sancho, M. Asunción Gómez, Daniel Morchón, Juan Carlos Montero, José María Sayagués, M. Dolores Ludeña, Emilio Fonseca
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Cancer Medicine
Subjects:
ctDNA
cyclin inhibitors
luminal breast cancer
PIK3CA
tissue
Online Access:https://doi.org/10.1002/cam4.70101
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