Neratinib enhances the efficacy of CDK4/6 inhibitor plus endocrine therapy in HR+/HER2-low breast cancer cell line ZR-75-1 via hsa-miR-23a-5p

Neratinib enhances the efficacy of CDK4/6 inhibitor plus endocrine therapy in HR+/HER2-low breast cancer cell line ZR-75-1 via hsa-miR-23a-5p

Abstract HR+/HER2-low breast cancer is a significant subgroup of conventional HR+/HER2-negative breast cancer, and combination of CDK4/6 inhibitor and endocrine therapy is the standard first-line and second-line treatments for advanced HR+/HER2-low breast cancer. Nevertheless, it remains uncertain w...

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Bibliographic Details
Main Authors: Liushan Chen, Lingling Ye, Yuqi Liang, Wei Luo, Qian Zuo, Ping Huang, Yuyu Hu, Yan Dai, Yingchao Wu, Qianqian Guo, Qianjun Chen
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Neratinib
HER2 mRNA stability
HR+/HER2-low
CDK4/6 inhibitor
Endocrine therapy
Hsa-miR-23a-5p
Online Access:https://doi.org/10.1038/s41598-024-82137-9
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