Associations of serum neurofilament and asthma: evidence from the NHANES 2013–2014
BackgroundNeural mechanisms are important in asthma, and serum neurofilament light chain (sNfL) is a biomarker of neuronal damage. This study investigated the correlation between sNfL and asthma.MethodsThis cross-sectional study was based on NHANES data and used multiple logistic regression analysis...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1567158/full |
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| author | Mingming Yang Xiao Qian Luqian Zhu Qiong Xu |
| author_facet | Mingming Yang Xiao Qian Luqian Zhu Qiong Xu |
| author_sort | Mingming Yang |
| collection | DOAJ |
| description | BackgroundNeural mechanisms are important in asthma, and serum neurofilament light chain (sNfL) is a biomarker of neuronal damage. This study investigated the correlation between sNfL and asthma.MethodsThis cross-sectional study was based on NHANES data and used multiple logistic regression analysis, subgroup analysis, and smoothed curve fitting to explore the relationship between sNfL and asthma. Covariate selection was validated using the variance inflation factor (VIF).ResultsThe study involved 1773 participants. Results showed that Ln-sNfL (OR = 1.39, 95% CI: 1.03–1.88, p = 0.0325) was positively associated with asthma. Subgroup analyses showed that age, gender, race, education level, marital status, family income, BMI, alcohol use, smoking, diabetes, hypertension and PAMs did not affect the positive association between sNfL and asthma (p > 0.05) (FDR corrected p > 0.1). E-value analysis suggested robustness to unmeasured confounding.ConclusionThere is a positive correlation between sNFL and asthma, and further large-scale and prospective studies are needed to replicate our results and assess the ability of sNfL to predict asthma. |
| format | Article |
| id | doaj-art-8c5b7fcb2b9d4d1892fa53712023359c |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-8c5b7fcb2b9d4d1892fa53712023359c2025-08-20T03:29:35ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.15671581567158Associations of serum neurofilament and asthma: evidence from the NHANES 2013–2014Mingming YangXiao QianLuqian ZhuQiong XuBackgroundNeural mechanisms are important in asthma, and serum neurofilament light chain (sNfL) is a biomarker of neuronal damage. This study investigated the correlation between sNfL and asthma.MethodsThis cross-sectional study was based on NHANES data and used multiple logistic regression analysis, subgroup analysis, and smoothed curve fitting to explore the relationship between sNfL and asthma. Covariate selection was validated using the variance inflation factor (VIF).ResultsThe study involved 1773 participants. Results showed that Ln-sNfL (OR = 1.39, 95% CI: 1.03–1.88, p = 0.0325) was positively associated with asthma. Subgroup analyses showed that age, gender, race, education level, marital status, family income, BMI, alcohol use, smoking, diabetes, hypertension and PAMs did not affect the positive association between sNfL and asthma (p > 0.05) (FDR corrected p > 0.1). E-value analysis suggested robustness to unmeasured confounding.ConclusionThere is a positive correlation between sNFL and asthma, and further large-scale and prospective studies are needed to replicate our results and assess the ability of sNfL to predict asthma.https://www.frontiersin.org/articles/10.3389/fneur.2025.1567158/fullasthmaserum neurofilament (sNfL)biomarkerneural mechanismNHANES |
| spellingShingle | Mingming Yang Xiao Qian Luqian Zhu Qiong Xu Associations of serum neurofilament and asthma: evidence from the NHANES 2013–2014 Frontiers in Neurology asthma serum neurofilament (sNfL) biomarker neural mechanism NHANES |
| title | Associations of serum neurofilament and asthma: evidence from the NHANES 2013–2014 |
| title_full | Associations of serum neurofilament and asthma: evidence from the NHANES 2013–2014 |
| title_fullStr | Associations of serum neurofilament and asthma: evidence from the NHANES 2013–2014 |
| title_full_unstemmed | Associations of serum neurofilament and asthma: evidence from the NHANES 2013–2014 |
| title_short | Associations of serum neurofilament and asthma: evidence from the NHANES 2013–2014 |
| title_sort | associations of serum neurofilament and asthma evidence from the nhanes 2013 2014 |
| topic | asthma serum neurofilament (sNfL) biomarker neural mechanism NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1567158/full |
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