Risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy, and their prevention: a review
The risk of thromboembolic complications associated with the use of combined oral contraceptives (COCs) and hormone replacement therapy is a concern for both physicians and patients. The work aimed to analyze existing data on the use of COCs and their associated thromboembolic risk. This review summ...
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Concilium Medicum
2025-01-01
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| Series: | КардиоСоматика |
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| Online Access: | https://cardiosomatics.ru/2221-7185/article/viewFile/640894/204323 |
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| author | Nina A. Suricova Anna S. Gluchova Evgeny E. Kravchenko Vladislav A. Vishnyakov Evgeny I. Mokin |
| author_facet | Nina A. Suricova Anna S. Gluchova Evgeny E. Kravchenko Vladislav A. Vishnyakov Evgeny I. Mokin |
| author_sort | Nina A. Suricova |
| collection | DOAJ |
| description | The risk of thromboembolic complications associated with the use of combined oral contraceptives (COCs) and hormone replacement therapy is a concern for both physicians and patients. The work aimed to analyze existing data on the use of COCs and their associated thromboembolic risk. This review summarizes the findings of Russian and international studies conducted in women using COCs who experienced thrombotic complications. A total of 37 sources were used, including articles indexed in international citation databases such as PubMed (MEDLINE) and Scopus, as well as foundational studies and monographs indexed in the Russian Science Citation Index (RSCI). Data were selected using the following keywords: сердечно-сосудистые заболевания (cardiovascular diseases), комбинированные оральные контрацептивы (combined oral contraceptives), КОК (COCs), тромбоэмболия лёгочной артерии (pulmonary embolism), ТЭЛА (PE), and инфаркт миокарда (myocardial infarction). Materials with unidentified authorship, educational manuals, pseudoscientific online sources, and publications not relevant to the topic were excluded.
The review revealed that the use of COCs may influence the risk of developing pulmonary embolism (PE); however, thrombus formation is also affected by additional factors. Some studies suggest that third- and fourth-generation COCs may be associated with a higher risk of PE, although the absolute risk remains relatively low. It is important to emphasize that the decision to initiate COC use and the selection of a specific drug should be made by a physician based on the patient’s individual characteristics, medical history, and risk factors. Notably, discontinuation of COCs does not eliminate the risk of PE entirely, as hereditary predisposition, lifestyle, and comorbid conditions may also contribute. |
| format | Article |
| id | doaj-art-8c538404bc894e8fbfba5db2da248060 |
| institution | DOAJ |
| issn | 2221-7185 2658-5707 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Concilium Medicum |
| record_format | Article |
| series | КардиоСоматика |
| spelling | doaj-art-8c538404bc894e8fbfba5db2da2480602025-08-20T03:06:58ZengConcilium MedicumКардиоСоматика2221-71852658-57072025-01-0116216817510.17816/CS64089476603Risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy, and their prevention: a reviewNina A. Suricova0https://orcid.org/0000-0001-8833-7043Anna S. Gluchova1https://orcid.org/0000-0001-8220-6739Evgeny E. Kravchenko2https://orcid.org/0009-0000-5178-4755Vladislav A. Vishnyakov3https://orcid.org/0009-0001-9554-7986Evgeny I. Mokin4https://orcid.org/0009-0004-2147-2805Orenburg State Medical UniversityOdont Medical CenterOrenburg State Medical UniversityOrenburg State Medical UniversityOrenburg State Medical UniversityThe risk of thromboembolic complications associated with the use of combined oral contraceptives (COCs) and hormone replacement therapy is a concern for both physicians and patients. The work aimed to analyze existing data on the use of COCs and their associated thromboembolic risk. This review summarizes the findings of Russian and international studies conducted in women using COCs who experienced thrombotic complications. A total of 37 sources were used, including articles indexed in international citation databases such as PubMed (MEDLINE) and Scopus, as well as foundational studies and monographs indexed in the Russian Science Citation Index (RSCI). Data were selected using the following keywords: сердечно-сосудистые заболевания (cardiovascular diseases), комбинированные оральные контрацептивы (combined oral contraceptives), КОК (COCs), тромбоэмболия лёгочной артерии (pulmonary embolism), ТЭЛА (PE), and инфаркт миокарда (myocardial infarction). Materials with unidentified authorship, educational manuals, pseudoscientific online sources, and publications not relevant to the topic were excluded. The review revealed that the use of COCs may influence the risk of developing pulmonary embolism (PE); however, thrombus formation is also affected by additional factors. Some studies suggest that third- and fourth-generation COCs may be associated with a higher risk of PE, although the absolute risk remains relatively low. It is important to emphasize that the decision to initiate COC use and the selection of a specific drug should be made by a physician based on the patient’s individual characteristics, medical history, and risk factors. Notably, discontinuation of COCs does not eliminate the risk of PE entirely, as hereditary predisposition, lifestyle, and comorbid conditions may also contribute.https://cardiosomatics.ru/2221-7185/article/viewFile/640894/204323risk factorscombined oral contraceptivespulmonary embolismcardiovascular diseases |
| spellingShingle | Nina A. Suricova Anna S. Gluchova Evgeny E. Kravchenko Vladislav A. Vishnyakov Evgeny I. Mokin Risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy, and their prevention: a review КардиоСоматика risk factors combined oral contraceptives pulmonary embolism cardiovascular diseases |
| title | Risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy, and their prevention: a review |
| title_full | Risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy, and their prevention: a review |
| title_fullStr | Risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy, and their prevention: a review |
| title_full_unstemmed | Risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy, and their prevention: a review |
| title_short | Risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy, and their prevention: a review |
| title_sort | risk of thromboembolic events in women using combined oral contraceptives and hormone replacement therapy and their prevention a review |
| topic | risk factors combined oral contraceptives pulmonary embolism cardiovascular diseases |
| url | https://cardiosomatics.ru/2221-7185/article/viewFile/640894/204323 |
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