Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells
Abstract In the context of tumorigenesis, telomere shortening is associated with apparent antagonistic outcomes: On one side, it favors cancer initiation through mechanisms involving genome instability, while on the other side, it prevents cancer progression, due to the activation of the DNA damage...
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| Format: | Article |
| Language: | English |
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Springer Nature
2019-06-01
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| Series: | EMBO Molecular Medicine |
| Online Access: | https://doi.org/10.15252/emmm.201910845 |
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| author | Julien Cherfils‐Vicini Eric Gilson |
| author_facet | Julien Cherfils‐Vicini Eric Gilson |
| author_sort | Julien Cherfils‐Vicini |
| collection | DOAJ |
| description | Abstract In the context of tumorigenesis, telomere shortening is associated with apparent antagonistic outcomes: On one side, it favors cancer initiation through mechanisms involving genome instability, while on the other side, it prevents cancer progression, due to the activation of the DNA damage response (DDR) checkpoint behaving as a cell‐intrinsic proliferation barrier. Consequently, telomerase, which can compensate for replicative erosion by adding telomeric DNA repeats at the chromosomal DNA extremities, is crucial for cancer progression and is upregulated in nearly 90% of human cancers. Therefore, telomeres are considered potential anti‐cancer targets and, to date, most of the studies have focused on telomerase inhibition. However, the development of clinically efficient telomerase targeting therapies is still in its infancy. In this context, the findings reported in this issue of EMBO Molecular Medicine by Bejarano et al (2019) open new avenues for alternative telomere therapies. |
| format | Article |
| id | doaj-art-8c50f1904e294cff8fe89299ee0fc6e8 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2019-06-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-8c50f1904e294cff8fe89299ee0fc6e82025-08-20T03:43:14ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842019-06-011171210.15252/emmm.201910845Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cellsJulien Cherfils‐Vicini0Eric Gilson1Université Côte d'Azur (UCA), Centre National de la Recherche Scientifique (CNRS) UMR7284, Institut National de la Santé et de la Recherche Médicale (INSERM) U1081, Institute for Research on Cancer and AgingUniversité Côte d'Azur (UCA), Centre National de la Recherche Scientifique (CNRS) UMR7284, Institut National de la Santé et de la Recherche Médicale (INSERM) U1081, Institute for Research on Cancer and AgingAbstract In the context of tumorigenesis, telomere shortening is associated with apparent antagonistic outcomes: On one side, it favors cancer initiation through mechanisms involving genome instability, while on the other side, it prevents cancer progression, due to the activation of the DNA damage response (DDR) checkpoint behaving as a cell‐intrinsic proliferation barrier. Consequently, telomerase, which can compensate for replicative erosion by adding telomeric DNA repeats at the chromosomal DNA extremities, is crucial for cancer progression and is upregulated in nearly 90% of human cancers. Therefore, telomeres are considered potential anti‐cancer targets and, to date, most of the studies have focused on telomerase inhibition. However, the development of clinically efficient telomerase targeting therapies is still in its infancy. In this context, the findings reported in this issue of EMBO Molecular Medicine by Bejarano et al (2019) open new avenues for alternative telomere therapies.https://doi.org/10.15252/emmm.201910845 |
| spellingShingle | Julien Cherfils‐Vicini Eric Gilson Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells EMBO Molecular Medicine |
| title | Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells |
| title_full | Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells |
| title_fullStr | Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells |
| title_full_unstemmed | Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells |
| title_short | Inhibiting TRF1 upstream signaling pathways to target telomeres in cancer cells |
| title_sort | inhibiting trf1 upstream signaling pathways to target telomeres in cancer cells |
| url | https://doi.org/10.15252/emmm.201910845 |
| work_keys_str_mv | AT juliencherfilsvicini inhibitingtrf1upstreamsignalingpathwaystotargettelomeresincancercells AT ericgilson inhibitingtrf1upstreamsignalingpathwaystotargettelomeresincancercells |