Inflammatory myofibroblastic tumor of the lung: a comprehensive narrative review of clinical and therapeutic insights
Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm classified by the World Health Organization as an intermediate malignancy with less than a 5% chance of metastasis. IMTs consist of myofibroblastic and spindle fibroblastic cells accompanied by inflammatory infiltration, primari...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2025-03-01
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| Series: | Polish Journal of Thoracic and Cardiovascular Surgery |
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| Online Access: | https://www.termedia.pl/Inflammatory-myofibroblastic-tumor-of-the-lung-a-comprehensive-narrative-review-of-clinical-and-therapeutic-insights,40,55758,1,1.html |
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| author | Vasileios Leivaditis Marianthi Baltagianni Elias Liolis Nikolaos Baltayiannis Gabriela Stanc Efthymia Souka Pella Batika Konstantinos Grapatsas Levan Tchabashvili Konstantinos Tasios Andreas Antzoulas Dimitrios Litsas Eleftherios Beltsios Manfred Dahm Athanasios Papatriantafyllou Efstratios Koletsis Francesk Mulita |
| author_facet | Vasileios Leivaditis Marianthi Baltagianni Elias Liolis Nikolaos Baltayiannis Gabriela Stanc Efthymia Souka Pella Batika Konstantinos Grapatsas Levan Tchabashvili Konstantinos Tasios Andreas Antzoulas Dimitrios Litsas Eleftherios Beltsios Manfred Dahm Athanasios Papatriantafyllou Efstratios Koletsis Francesk Mulita |
| author_sort | Vasileios Leivaditis |
| collection | DOAJ |
| description | Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm classified by the World Health Organization as an intermediate malignancy with less than a 5% chance of metastasis. IMTs consist of myofibroblastic and spindle fibroblastic cells accompanied by inflammatory infiltration, primarily affecting patients under 16 years old, though they can also occur in adults. The etiology and pathogenesis of IMTs remain unclear, with possible contributing factors including inflammation, trauma, autoimmune diseases, prior surgery, viral infections, and uncontrolled myofibroblast proliferation. The primary treatment is complete surgical resection, which is associated with long-term survival and a significantly reduced recurrence rate of 2%, compared to 60% for incomplete resections. Chemotherapy is generally not recommended but may be necessary for unresectable tumors. Advances in histopathological diagnosis provide deeper insights into IMT biology, aiding in the selection of appropriate treatments. This paper presents a comprehensive review of the literature on this rare clinical entity. |
| format | Article |
| id | doaj-art-8c4cfe8c6e1e4d2e876a5cd3ed7e3a70 |
| institution | OA Journals |
| issn | 1731-5530 1897-4252 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Thoracic and Cardiovascular Surgery |
| spelling | doaj-art-8c4cfe8c6e1e4d2e876a5cd3ed7e3a702025-08-20T02:24:54ZengTermedia Publishing HousePolish Journal of Thoracic and Cardiovascular Surgery1731-55301897-42522025-03-01221324310.5114/kitp.2025.14851455758Inflammatory myofibroblastic tumor of the lung: a comprehensive narrative review of clinical and therapeutic insightsVasileios LeivaditisMarianthi BaltagianniElias LiolisNikolaos BaltayiannisGabriela StancEfthymia SoukaPella BatikaKonstantinos GrapatsasLevan TchabashviliKonstantinos TasiosAndreas AntzoulasDimitrios LitsasEleftherios BeltsiosManfred DahmAthanasios PapatriantafyllouEfstratios KoletsisFrancesk MulitaInflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm classified by the World Health Organization as an intermediate malignancy with less than a 5% chance of metastasis. IMTs consist of myofibroblastic and spindle fibroblastic cells accompanied by inflammatory infiltration, primarily affecting patients under 16 years old, though they can also occur in adults. The etiology and pathogenesis of IMTs remain unclear, with possible contributing factors including inflammation, trauma, autoimmune diseases, prior surgery, viral infections, and uncontrolled myofibroblast proliferation. The primary treatment is complete surgical resection, which is associated with long-term survival and a significantly reduced recurrence rate of 2%, compared to 60% for incomplete resections. Chemotherapy is generally not recommended but may be necessary for unresectable tumors. Advances in histopathological diagnosis provide deeper insights into IMT biology, aiding in the selection of appropriate treatments. This paper presents a comprehensive review of the literature on this rare clinical entity.https://www.termedia.pl/Inflammatory-myofibroblastic-tumor-of-the-lung-a-comprehensive-narrative-review-of-clinical-and-therapeutic-insights,40,55758,1,1.htmlinflammatory myofibroblastic tumor mesenchymal tumor pulmonary inflammatory myofibroblastic tumor myofibroblastic proliferation rare lung tumor |
| spellingShingle | Vasileios Leivaditis Marianthi Baltagianni Elias Liolis Nikolaos Baltayiannis Gabriela Stanc Efthymia Souka Pella Batika Konstantinos Grapatsas Levan Tchabashvili Konstantinos Tasios Andreas Antzoulas Dimitrios Litsas Eleftherios Beltsios Manfred Dahm Athanasios Papatriantafyllou Efstratios Koletsis Francesk Mulita Inflammatory myofibroblastic tumor of the lung: a comprehensive narrative review of clinical and therapeutic insights Polish Journal of Thoracic and Cardiovascular Surgery inflammatory myofibroblastic tumor mesenchymal tumor pulmonary inflammatory myofibroblastic tumor myofibroblastic proliferation rare lung tumor |
| title | Inflammatory myofibroblastic tumor of the lung: a comprehensive narrative review of clinical and therapeutic insights |
| title_full | Inflammatory myofibroblastic tumor of the lung: a comprehensive narrative review of clinical and therapeutic insights |
| title_fullStr | Inflammatory myofibroblastic tumor of the lung: a comprehensive narrative review of clinical and therapeutic insights |
| title_full_unstemmed | Inflammatory myofibroblastic tumor of the lung: a comprehensive narrative review of clinical and therapeutic insights |
| title_short | Inflammatory myofibroblastic tumor of the lung: a comprehensive narrative review of clinical and therapeutic insights |
| title_sort | inflammatory myofibroblastic tumor of the lung a comprehensive narrative review of clinical and therapeutic insights |
| topic | inflammatory myofibroblastic tumor mesenchymal tumor pulmonary inflammatory myofibroblastic tumor myofibroblastic proliferation rare lung tumor |
| url | https://www.termedia.pl/Inflammatory-myofibroblastic-tumor-of-the-lung-a-comprehensive-narrative-review-of-clinical-and-therapeutic-insights,40,55758,1,1.html |
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