The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic Patients
Аim: to study the structural and functional characteristics of albumin in patients with decompensated cirrhosis, their relationship with ascites; to identify the relationship between improvement in albumin characteristics and regression of ascites.Materials and methods. Fifty patients with decompens...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2023-09-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/838 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860057904775168 |
|---|---|
| author | A. A. Turkina M. V. Maevskaya M. S. Zharkova V. T. Ivashkin |
| author_facet | A. A. Turkina M. V. Maevskaya M. S. Zharkova V. T. Ivashkin |
| author_sort | A. A. Turkina |
| collection | DOAJ |
| description | Аim: to study the structural and functional characteristics of albumin in patients with decompensated cirrhosis, their relationship with ascites; to identify the relationship between improvement in albumin characteristics and regression of ascites.Materials and methods. Fifty patients with decompensated liver cirrhosis and ascites were divided into groups. The first group received standard treatment for cirrhosis, the second — standard treatment and replacement therapy with 20 % human albumin solution at a dose of 200 mL per week for 3 months.Results. The value of the native conformation of albumin and the functional parameters of albumin were significantly lower than in the group of healthy individuals (p < 0.001). With the severity of ascites, the native conformation index (DR), which characterizes the structural usefulness of the albumin molecule, decreased. Median DR for ascites stage I (IAC) was –1.69, II grade — –2.28, III grade — –2.42 (p < 0.05). Replacement therapy with albumin allowed to achieve regression of ascites in 48.4 % of patients, compared with 7.1 % in the standard treatment group. Along with clinical improvement, restoration of albumin structural and functional properties was observed in the albumin group. The mean serum albumin level at which ascites remained in remission for 3 months was 42.11 g/L (p < 0.001).Conclusions and discussion. The structural and functional characteristics of albumin were impaired in patients with decompensated cirrhosis and ascites. The severity of changes in the structural and functional properties of albumin depended on the severity of ascites. The regression of ascites was accompanied by the restoration of the functional and structural usefulness of albumin against the backdrop of albumin replacement therapy. The criterion for stopping transfusion therapy with albumin can be the achievement of a serum albumin level of 42.11 ± 7.04 g/L, DR — 1.05, BE — 73.51 %, RTQ — 75.10 %, DTE — 72.71 %. |
| format | Article |
| id | doaj-art-8c4ca2cecb2b4eadb3fe8bf721901bc2 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2023-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-8c4ca2cecb2b4eadb3fe8bf721901bc22025-02-10T16:14:38ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732023-09-01333434810.22416/1382-4376-2023-33-3-43-48552The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic PatientsA. A. Turkina0M. V. Maevskaya1M. S. Zharkova2V. T. Ivashkin3I.M. Sechenov First Moscow University (Sechenov University)I.M. Sechenov First Moscow University (Sechenov University)I.M. Sechenov First Moscow University (Sechenov University)I.M. Sechenov First Moscow University (Sechenov University)Аim: to study the structural and functional characteristics of albumin in patients with decompensated cirrhosis, their relationship with ascites; to identify the relationship between improvement in albumin characteristics and regression of ascites.Materials and methods. Fifty patients with decompensated liver cirrhosis and ascites were divided into groups. The first group received standard treatment for cirrhosis, the second — standard treatment and replacement therapy with 20 % human albumin solution at a dose of 200 mL per week for 3 months.Results. The value of the native conformation of albumin and the functional parameters of albumin were significantly lower than in the group of healthy individuals (p < 0.001). With the severity of ascites, the native conformation index (DR), which characterizes the structural usefulness of the albumin molecule, decreased. Median DR for ascites stage I (IAC) was –1.69, II grade — –2.28, III grade — –2.42 (p < 0.05). Replacement therapy with albumin allowed to achieve regression of ascites in 48.4 % of patients, compared with 7.1 % in the standard treatment group. Along with clinical improvement, restoration of albumin structural and functional properties was observed in the albumin group. The mean serum albumin level at which ascites remained in remission for 3 months was 42.11 g/L (p < 0.001).Conclusions and discussion. The structural and functional characteristics of albumin were impaired in patients with decompensated cirrhosis and ascites. The severity of changes in the structural and functional properties of albumin depended on the severity of ascites. The regression of ascites was accompanied by the restoration of the functional and structural usefulness of albumin against the backdrop of albumin replacement therapy. The criterion for stopping transfusion therapy with albumin can be the achievement of a serum albumin level of 42.11 ± 7.04 g/L, DR — 1.05, BE — 73.51 %, RTQ — 75.10 %, DTE — 72.71 %.https://www.gastro-j.ru/jour/article/view/838drbertqdteepralbumin transfusionsalbumin replacement therapyascites |
| spellingShingle | A. A. Turkina M. V. Maevskaya M. S. Zharkova V. T. Ivashkin The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic Patients Российский журнал гастроэнтерологии, гепатологии, колопроктологии dr be rtq dte epr albumin transfusions albumin replacement therapy ascites |
| title | The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic Patients |
| title_full | The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic Patients |
| title_fullStr | The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic Patients |
| title_full_unstemmed | The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic Patients |
| title_short | The Role of Correcting Structural and Functional Albumin Properties in Ascites Control in Decompensated Cirrhotic Patients |
| title_sort | role of correcting structural and functional albumin properties in ascites control in decompensated cirrhotic patients |
| topic | dr be rtq dte epr albumin transfusions albumin replacement therapy ascites |
| url | https://www.gastro-j.ru/jour/article/view/838 |
| work_keys_str_mv | AT aaturkina theroleofcorrectingstructuralandfunctionalalbuminpropertiesinascitescontrolindecompensatedcirrhoticpatients AT mvmaevskaya theroleofcorrectingstructuralandfunctionalalbuminpropertiesinascitescontrolindecompensatedcirrhoticpatients AT mszharkova theroleofcorrectingstructuralandfunctionalalbuminpropertiesinascitescontrolindecompensatedcirrhoticpatients AT vtivashkin theroleofcorrectingstructuralandfunctionalalbuminpropertiesinascitescontrolindecompensatedcirrhoticpatients AT aaturkina roleofcorrectingstructuralandfunctionalalbuminpropertiesinascitescontrolindecompensatedcirrhoticpatients AT mvmaevskaya roleofcorrectingstructuralandfunctionalalbuminpropertiesinascitescontrolindecompensatedcirrhoticpatients AT mszharkova roleofcorrectingstructuralandfunctionalalbuminpropertiesinascitescontrolindecompensatedcirrhoticpatients AT vtivashkin roleofcorrectingstructuralandfunctionalalbuminpropertiesinascitescontrolindecompensatedcirrhoticpatients |