Interplay of ST2 downregulation and inflammatory dysregulation in hypertrophic cardiomyopathy pathogenesis

Interplay of ST2 downregulation and inflammatory dysregulation in hypertrophic cardiomyopathy pathogenesis

BackgroundHypertrophic Cardiomyopathy (HCM) is an inherited heart disease and the pathogenesis of HCM involves genetic mutations, hemodynamic stress, and metabolic factors, with myocardial fibrosis playing a crucial role in severe clinical events. IL-33/ST2 signaling pathway known for its roles in i...

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Bibliographic Details
Main Authors: Xingyu Cao, Huawei Wang, Zunsong Hu, Wenfang Ma, Peng Ding, Huang Sun, Xiying Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
hypertrophic cardiomyopathy (HCM)
ST2
inflammation
myocardial fibrosis
RNA sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1511415/full
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