Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats
Relevance. Alcoholic cardiomyopathy (ACMP) is the leading cause of mortality in chronic disease, which is largely associated with an increased risk of developing malignant diseases of the cardiovascular disease. Search for new drugs, including those exhibiting pronounced antiarrhythmic activity, sup...
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| Format: | Article |
| Language: | Russian |
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LLC “Publisher OKI”
2023-07-01
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| Series: | Фармакокинетика и Фармакодинамика |
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| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/367 |
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| author | S. L. Smirnova I. M. Roshchevskaya V. V. Barchukov I. B. Tsorin S. A. Kryzhanovskii |
| author_facet | S. L. Smirnova I. M. Roshchevskaya V. V. Barchukov I. B. Tsorin S. A. Kryzhanovskii |
| author_sort | S. L. Smirnova |
| collection | DOAJ |
| description | Relevance. Alcoholic cardiomyopathy (ACMP) is the leading cause of mortality in chronic disease, which is largely associated with an increased risk of developing malignant diseases of the cardiovascular disease. Search for new drugs, including those exhibiting pronounced antiarrhythmic activity, supposed relevance. Objective. To study the effect of combination therapy with fabomotizole and ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats. Methods. The sequence of depolarization of the atrial epicardium was studied in rats in a translational model of alcoholic cardiomyopathy, which received a combination of fabomotizole and compound ALM-802 daily for 28 days after the end of 24 weeks of alcoholization, or pyrogen-free water intraperitoneally. Results. As a result of the 28-day combined action of fabomotizole and the compound ALM-802 in animals with alcoholic cardiomyopathy, additional areas of early activation in the area of lacunae of the pulmonary veins that form during the 24-week period of alcoholization disappear, the risk of atrial arrhythmias is minimized, and sequential propagation. |
| format | Article |
| id | doaj-art-8c3f1e25ec8d45299c17ec2fff17907e |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2023-07-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-8c3f1e25ec8d45299c17ec2fff17907e2025-08-20T03:57:48ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302023-07-0102141910.37489/2587-7836-2023-2-14-19332Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in ratsS. L. Smirnova0I. M. Roshchevskaya1V. V. Barchukov2I. B. Tsorin3S. A. Kryzhanovskii4FRC "Komi Science Centre of the Ural Branch ofthe Russian Academy of Sciences"FSBI "Research Zakusov Institue of Pharmacology"FSBI "Research Zakusov Institue of Pharmacology"FSBI "Research Zakusov Institue of Pharmacology"FSBI "Research Zakusov Institue of Pharmacology"Relevance. Alcoholic cardiomyopathy (ACMP) is the leading cause of mortality in chronic disease, which is largely associated with an increased risk of developing malignant diseases of the cardiovascular disease. Search for new drugs, including those exhibiting pronounced antiarrhythmic activity, supposed relevance. Objective. To study the effect of combination therapy with fabomotizole and ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats. Methods. The sequence of depolarization of the atrial epicardium was studied in rats in a translational model of alcoholic cardiomyopathy, which received a combination of fabomotizole and compound ALM-802 daily for 28 days after the end of 24 weeks of alcoholization, or pyrogen-free water intraperitoneally. Results. As a result of the 28-day combined action of fabomotizole and the compound ALM-802 in animals with alcoholic cardiomyopathy, additional areas of early activation in the area of lacunae of the pulmonary veins that form during the 24-week period of alcoholization disappear, the risk of atrial arrhythmias is minimized, and sequential propagation.https://www.pharmacokinetica.ru/jour/article/view/367alcoholic cardiomyopathyfabomotizolecompound alm-802atrial depolarization |
| spellingShingle | S. L. Smirnova I. M. Roshchevskaya V. V. Barchukov I. B. Tsorin S. A. Kryzhanovskii Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats Фармакокинетика и Фармакодинамика alcoholic cardiomyopathy fabomotizole compound alm-802 atrial depolarization |
| title | Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats |
| title_full | Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats |
| title_fullStr | Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats |
| title_full_unstemmed | Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats |
| title_short | Combined effect of fabomotizol and the compound ALM-802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats |
| title_sort | combined effect of fabomotizol and the compound alm 802 on atrial depolarization in a translational model of alcoholic cardiomyopathy in rats |
| topic | alcoholic cardiomyopathy fabomotizole compound alm-802 atrial depolarization |
| url | https://www.pharmacokinetica.ru/jour/article/view/367 |
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