Impacts of micro- and nanoplastic exposure on the cardiovascular system: a systematic review focused on in vivo studies

Microplastics and nanoplastics, degraded plastic polymers, are increasing in the environment, raising concerns about their potential health impacts, particularly on the cardiovascular system. This systematic review aimed to investigate the prospective effects of MPs and NPs on cardiovascular toxicit...

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Main Authors: Hikmawan Wahyu Sulistomo, Muhammad Reva Aditya, Athaya Rahmanardi Muhammad, Oktivani Adelathifa Rahma
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:All Life
Subjects:
Online Access:http://dx.doi.org/10.1080/26895293.2024.2409835
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author Hikmawan Wahyu Sulistomo
Muhammad Reva Aditya
Athaya Rahmanardi Muhammad
Oktivani Adelathifa Rahma
author_facet Hikmawan Wahyu Sulistomo
Muhammad Reva Aditya
Athaya Rahmanardi Muhammad
Oktivani Adelathifa Rahma
author_sort Hikmawan Wahyu Sulistomo
collection DOAJ
description Microplastics and nanoplastics, degraded plastic polymers, are increasing in the environment, raising concerns about their potential health impacts, particularly on the cardiovascular system. This systematic review aimed to investigate the prospective effects of MPs and NPs on cardiovascular toxicity. This study was written following the PRISMA 2020 guidelines. The risk of bias in the included studies was assessed using the SYRCLE tool. Our review included 38 in vivo studies dating back from 2017 to 2024 from several databases, including PubMed, ScienceDirect, SpringerLink, Taylor & Francis, ProQuest, and Wiley Online Library, with inclusion criteria of (PECOS) (1) Population: Animal; (2) Exposure: All types of exposure to micro nanoplastics; (3) Comparison: Placebo/ Control; (4) Outcome: Cardiotoxicity, inhibition of development of cardiovascular tissue, oxidative stress, inflammation, and abnormal structure; and (5) Study design: In vivo experimental study. Studies reveal that MPs and NPs cause cardiovascular toxicity through deposition, morphological changes, biomarker alterations, metabolism changes, and genetic regulation related to injury, inflammation, and oxidative stress. This study is limited to the comparison of the different particle sizes, dose of exposure, and duration of exposure effects toward cardiotoxicity, and does not compare the different effects of toxicity between different particle types.
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institution Kabale University
issn 2689-5307
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publishDate 2024-12-01
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series All Life
spelling doaj-art-8c3ecbc14a324f89b75a67ca974c6c732025-01-20T14:38:00ZengTaylor & Francis GroupAll Life2689-53072024-12-01170110.1080/26895293.2024.24098352409835Impacts of micro- and nanoplastic exposure on the cardiovascular system: a systematic review focused on in vivo studiesHikmawan Wahyu Sulistomo0Muhammad Reva Aditya1Athaya Rahmanardi Muhammad2Oktivani Adelathifa Rahma3Universitas BrawijayaUniversitas BrawijayaUniversitas BrawijayaUniversitas BrawijayaMicroplastics and nanoplastics, degraded plastic polymers, are increasing in the environment, raising concerns about their potential health impacts, particularly on the cardiovascular system. This systematic review aimed to investigate the prospective effects of MPs and NPs on cardiovascular toxicity. This study was written following the PRISMA 2020 guidelines. The risk of bias in the included studies was assessed using the SYRCLE tool. Our review included 38 in vivo studies dating back from 2017 to 2024 from several databases, including PubMed, ScienceDirect, SpringerLink, Taylor & Francis, ProQuest, and Wiley Online Library, with inclusion criteria of (PECOS) (1) Population: Animal; (2) Exposure: All types of exposure to micro nanoplastics; (3) Comparison: Placebo/ Control; (4) Outcome: Cardiotoxicity, inhibition of development of cardiovascular tissue, oxidative stress, inflammation, and abnormal structure; and (5) Study design: In vivo experimental study. Studies reveal that MPs and NPs cause cardiovascular toxicity through deposition, morphological changes, biomarker alterations, metabolism changes, and genetic regulation related to injury, inflammation, and oxidative stress. This study is limited to the comparison of the different particle sizes, dose of exposure, and duration of exposure effects toward cardiotoxicity, and does not compare the different effects of toxicity between different particle types.http://dx.doi.org/10.1080/26895293.2024.2409835microplasticnanoplasticcardiovascular toxicityanimal study
spellingShingle Hikmawan Wahyu Sulistomo
Muhammad Reva Aditya
Athaya Rahmanardi Muhammad
Oktivani Adelathifa Rahma
Impacts of micro- and nanoplastic exposure on the cardiovascular system: a systematic review focused on in vivo studies
All Life
microplastic
nanoplastic
cardiovascular toxicity
animal study
title Impacts of micro- and nanoplastic exposure on the cardiovascular system: a systematic review focused on in vivo studies
title_full Impacts of micro- and nanoplastic exposure on the cardiovascular system: a systematic review focused on in vivo studies
title_fullStr Impacts of micro- and nanoplastic exposure on the cardiovascular system: a systematic review focused on in vivo studies
title_full_unstemmed Impacts of micro- and nanoplastic exposure on the cardiovascular system: a systematic review focused on in vivo studies
title_short Impacts of micro- and nanoplastic exposure on the cardiovascular system: a systematic review focused on in vivo studies
title_sort impacts of micro and nanoplastic exposure on the cardiovascular system a systematic review focused on in vivo studies
topic microplastic
nanoplastic
cardiovascular toxicity
animal study
url http://dx.doi.org/10.1080/26895293.2024.2409835
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AT athayarahmanardimuhammad impactsofmicroandnanoplasticexposureonthecardiovascularsystemasystematicreviewfocusedoninvivostudies
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