Lactylation in tumor: mechanisms and therapeutic potentials

Lactylation in tumor: mechanisms and therapeutic potentials

Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation. Metabolic reprogramming is a key feature of tumor cells and highlights the important role of lactylation in ca...

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Bibliographic Details
Main Authors: Dandan Wang, Hao Rong, Ke Ma, Jun Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
lactate
lactylation
post-translational modifications
tumor metabolism
tumor microenvironment
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609596/full
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