Lactylation in tumor: mechanisms and therapeutic potentials
Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation. Metabolic reprogramming is a key feature of tumor cells and highlights the important role of lactylation in ca...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609596/full |
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| _version_ | 1849335537417060352 |
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| author | Dandan Wang Hao Rong Ke Ma Jun Peng |
| author_facet | Dandan Wang Hao Rong Ke Ma Jun Peng |
| author_sort | Dandan Wang |
| collection | DOAJ |
| description | Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation. Metabolic reprogramming is a key feature of tumor cells and highlights the important role of lactylation in cancer development. Recent studies have emphasized the significant regulatory roles of lactylation in cancer, suggesting that it may serve as a potential target for treatment. This review discusses the mechanisms, regulation, and functions of lactylation in cancer. It also explores the possible significance of lactylation as a marker for the diagnosis and therapy of tumor, and evaluates the therapeutic prospects of targeting lactylation. While the precise mechanisms of lactylation in cancer regulation require further investigation, its significant influence indicates promising avenues for future research. |
| format | Article |
| id | doaj-art-8c3bb06a876c4b699e64622d4163a2a3 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-8c3bb06a876c4b699e64622d4163a2a32025-08-20T03:45:14ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-06-011610.3389/fimmu.2025.16095961609596Lactylation in tumor: mechanisms and therapeutic potentialsDandan WangHao RongKe MaJun PengLactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation. Metabolic reprogramming is a key feature of tumor cells and highlights the important role of lactylation in cancer development. Recent studies have emphasized the significant regulatory roles of lactylation in cancer, suggesting that it may serve as a potential target for treatment. This review discusses the mechanisms, regulation, and functions of lactylation in cancer. It also explores the possible significance of lactylation as a marker for the diagnosis and therapy of tumor, and evaluates the therapeutic prospects of targeting lactylation. While the precise mechanisms of lactylation in cancer regulation require further investigation, its significant influence indicates promising avenues for future research.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609596/fulllactatelactylationpost-translational modificationstumor metabolismtumor microenvironment |
| spellingShingle | Dandan Wang Hao Rong Ke Ma Jun Peng Lactylation in tumor: mechanisms and therapeutic potentials Frontiers in Immunology lactate lactylation post-translational modifications tumor metabolism tumor microenvironment |
| title | Lactylation in tumor: mechanisms and therapeutic potentials |
| title_full | Lactylation in tumor: mechanisms and therapeutic potentials |
| title_fullStr | Lactylation in tumor: mechanisms and therapeutic potentials |
| title_full_unstemmed | Lactylation in tumor: mechanisms and therapeutic potentials |
| title_short | Lactylation in tumor: mechanisms and therapeutic potentials |
| title_sort | lactylation in tumor mechanisms and therapeutic potentials |
| topic | lactate lactylation post-translational modifications tumor metabolism tumor microenvironment |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1609596/full |
| work_keys_str_mv | AT dandanwang lactylationintumormechanismsandtherapeuticpotentials AT haorong lactylationintumormechanismsandtherapeuticpotentials AT kema lactylationintumormechanismsandtherapeuticpotentials AT junpeng lactylationintumormechanismsandtherapeuticpotentials |