Assessment of Anti-tyrosinase and Antioxidant Activities along with Molecular Docking Studies, and in silico ADME of Some 3-Hydroxypyridin-4-one Derivatives
Tyrosinase is an essential enzyme in melanin production, which plays an important role in the browning of plants and vegetables and skin diseases in humans. Therefore, the design and synthesis of tyrosinase inhibitors are important in the food industry and in treating melanin-related skin diseases....
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2024-09-01
|
| Series: | Trends in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://tips.sums.ac.ir/article_50426_31548a870fcba6a713ed7037cfaab36f.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850196458327769088 |
|---|---|
| author | Fateme Zare Sara Sadeghian Mehdi Khoshneviszadeh Mojgan Pasbani Razieh Sabet Hossein Sadeghpour |
| author_facet | Fateme Zare Sara Sadeghian Mehdi Khoshneviszadeh Mojgan Pasbani Razieh Sabet Hossein Sadeghpour |
| author_sort | Fateme Zare |
| collection | DOAJ |
| description | Tyrosinase is an essential enzyme in melanin production, which plays an important role in the browning of plants and vegetables and skin diseases in humans. Therefore, the design and synthesis of tyrosinase inhibitors are important in the food industry and in treating melanin-related skin diseases. In this study, the tyrosinase inhibitory activity and the antioxidant capacity of a series of 3-hydroxypyridin-4-one derivatives that have been synthesized in the Department of Medicinal Chemistry at the Faculty of Pharmacy, Shiraz University of Medical Sciences, were assessed. The antioxidant activities were evaluated using the 1,1-diphenyl-2-picrylhydrazine (DPPH) radical scavenging method. The biological results indicated that these derivatives exhibit mild anti-tyrosinase and antioxidant properties. Docking studies were also conducted, and the results showed that the compounds have suitable binding free energy and interactions with the active site of the tyrosinase enzyme, which were not consistent with the biological results. Finally, the investigation of the pharmacokinetic characteristics and drug-likeness of the derivatives showed that they have the potential for oral bioavailability. |
| format | Article |
| id | doaj-art-8c36efbc2a194654bdb08beaba765998 |
| institution | OA Journals |
| issn | 2423-5652 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Trends in Pharmaceutical Sciences |
| spelling | doaj-art-8c36efbc2a194654bdb08beaba7659982025-08-20T02:13:27ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522024-09-0110325125810.30476/tips.2024.103318.124950426Assessment of Anti-tyrosinase and Antioxidant Activities along with Molecular Docking Studies, and in silico ADME of Some 3-Hydroxypyridin-4-one DerivativesFateme Zare0Sara Sadeghian1Mehdi Khoshneviszadeh2Mojgan Pasbani3Razieh Sabet4Hossein Sadeghpour5Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Tyrosinase is an essential enzyme in melanin production, which plays an important role in the browning of plants and vegetables and skin diseases in humans. Therefore, the design and synthesis of tyrosinase inhibitors are important in the food industry and in treating melanin-related skin diseases. In this study, the tyrosinase inhibitory activity and the antioxidant capacity of a series of 3-hydroxypyridin-4-one derivatives that have been synthesized in the Department of Medicinal Chemistry at the Faculty of Pharmacy, Shiraz University of Medical Sciences, were assessed. The antioxidant activities were evaluated using the 1,1-diphenyl-2-picrylhydrazine (DPPH) radical scavenging method. The biological results indicated that these derivatives exhibit mild anti-tyrosinase and antioxidant properties. Docking studies were also conducted, and the results showed that the compounds have suitable binding free energy and interactions with the active site of the tyrosinase enzyme, which were not consistent with the biological results. Finally, the investigation of the pharmacokinetic characteristics and drug-likeness of the derivatives showed that they have the potential for oral bioavailability.https://tips.sums.ac.ir/article_50426_31548a870fcba6a713ed7037cfaab36f.pdf3-hydroxypyridin-4-onetyrosinase inhibitorfree radical scavengingadme |
| spellingShingle | Fateme Zare Sara Sadeghian Mehdi Khoshneviszadeh Mojgan Pasbani Razieh Sabet Hossein Sadeghpour Assessment of Anti-tyrosinase and Antioxidant Activities along with Molecular Docking Studies, and in silico ADME of Some 3-Hydroxypyridin-4-one Derivatives Trends in Pharmaceutical Sciences 3-hydroxypyridin-4-one tyrosinase inhibitor free radical scavenging adme |
| title | Assessment of Anti-tyrosinase and Antioxidant Activities along with Molecular Docking Studies, and in silico ADME of Some 3-Hydroxypyridin-4-one Derivatives |
| title_full | Assessment of Anti-tyrosinase and Antioxidant Activities along with Molecular Docking Studies, and in silico ADME of Some 3-Hydroxypyridin-4-one Derivatives |
| title_fullStr | Assessment of Anti-tyrosinase and Antioxidant Activities along with Molecular Docking Studies, and in silico ADME of Some 3-Hydroxypyridin-4-one Derivatives |
| title_full_unstemmed | Assessment of Anti-tyrosinase and Antioxidant Activities along with Molecular Docking Studies, and in silico ADME of Some 3-Hydroxypyridin-4-one Derivatives |
| title_short | Assessment of Anti-tyrosinase and Antioxidant Activities along with Molecular Docking Studies, and in silico ADME of Some 3-Hydroxypyridin-4-one Derivatives |
| title_sort | assessment of anti tyrosinase and antioxidant activities along with molecular docking studies and in silico adme of some 3 hydroxypyridin 4 one derivatives |
| topic | 3-hydroxypyridin-4-one tyrosinase inhibitor free radical scavenging adme |
| url | https://tips.sums.ac.ir/article_50426_31548a870fcba6a713ed7037cfaab36f.pdf |
| work_keys_str_mv | AT fatemezare assessmentofantityrosinaseandantioxidantactivitiesalongwithmoleculardockingstudiesandinsilicoadmeofsome3hydroxypyridin4onederivatives AT sarasadeghian assessmentofantityrosinaseandantioxidantactivitiesalongwithmoleculardockingstudiesandinsilicoadmeofsome3hydroxypyridin4onederivatives AT mehdikhoshneviszadeh assessmentofantityrosinaseandantioxidantactivitiesalongwithmoleculardockingstudiesandinsilicoadmeofsome3hydroxypyridin4onederivatives AT mojganpasbani assessmentofantityrosinaseandantioxidantactivitiesalongwithmoleculardockingstudiesandinsilicoadmeofsome3hydroxypyridin4onederivatives AT raziehsabet assessmentofantityrosinaseandantioxidantactivitiesalongwithmoleculardockingstudiesandinsilicoadmeofsome3hydroxypyridin4onederivatives AT hosseinsadeghpour assessmentofantityrosinaseandantioxidantactivitiesalongwithmoleculardockingstudiesandinsilicoadmeofsome3hydroxypyridin4onederivatives |