CNV-mediated dysregulation of the ceRNA network mechanism revealed heterogeneity in diffuse and intestinal gastric cancers

CNV-mediated dysregulation of the ceRNA network mechanism revealed heterogeneity in diffuse and intestinal gastric cancers

Abstract Background Gastric cancer (GC) is a highly heterogeneous tumour with high morbidity. Approximately 95% of GC cases are gastric adenocarcinomas, which are further categorized into two predominant subtypes: diffuse gastric cancer (DGC) and intestinal gastric cancer (IGC). These subtypes exhib...

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Main Authors: Rongji Xu, Danni He, Rui Sun, Jiaqi Zhou, Mengyu Xin, Qian Liu, Yifan Dai, Houxing Li, Yujie Zhang, Jiatong Li, XinXin Shan, Yuting He, Borui Xu, Qiuyan Guo, Shangwei Ning, Yue Gao, Peng Wang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Diffuse gastric cancer
Intestinal gastric cancer
CNV
CeRNA
Driver genes
Tumour heterogeneity
Online Access:https://doi.org/10.1186/s12967-025-06222-x
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