Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults.
<h4>Background</h4>The precise link between dietary consumption of n-3 and n-6 fatty acids and hyperuricemia remains equivocal. Accordingly, the purpose of the current investigation is to clarify any possible associations between the consumption of n-3 and n-6 fatty acids and hyperuricem...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0317490 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849327870019633152 |
|---|---|
| author | Huakai Wang Chao Zhang Yuxin Sun Sirui Sun Zhe Wang Honggang Xiang |
| author_facet | Huakai Wang Chao Zhang Yuxin Sun Sirui Sun Zhe Wang Honggang Xiang |
| author_sort | Huakai Wang |
| collection | DOAJ |
| description | <h4>Background</h4>The precise link between dietary consumption of n-3 and n-6 fatty acids and hyperuricemia remains equivocal. Accordingly, the purpose of the current investigation is to clarify any possible associations between the consumption of n-3 and n-6 fatty acids and hyperuricemia in the context of American adults.<h4>Materials and methods</h4>The present investigation employed a cross-sectional design, comprising a sample of 21,120 American adults above the age of 20 from the National Health and Nutrition Examination Survey (NHANES) waves between 2007 and 2016. The dietary consumption of n-3 and n-6 fatty acids was measured through two 24-h dietary recall interviews. To assess the relationships of dietary consumption of n3 and n6 fatty acids with hyperuricemia, we applied multivariable logistic regression, t tests, chi-square tests, and restricted cubic spline. To determine the robustness of our findings, sensitivity analyses were also carried out.<h4>Results</h4>The results of the multivariable logistic regression models indicated a significant correlation between dietary consumption of n3 and n6 fatty acids and hyperuricemia. The ORs with 95% CIs of hyperuricemia for the highest tertile versus lowest tertile of dietary consumption of n3 and n6 fatty acids were 0.76 (0.66, 0.88) (p < 0.001) and 0.72 (0.64, 0.82) (p < 0.001), respectively. Moreover, dose‒response analyses revealed a linear relationship between n-3 and n-6 fatty acid consumption and the risk of hyperuricemia.<h4>Conclusion</h4>The findings of this study indicate a significant inverse correlation between the dietary consumption of n3 and n6 fatty acids and hyperuricemia in the US adult population. Notably, there was no significant relationship between the n6:n3 ratio and hyperuricemia. |
| format | Article |
| id | doaj-art-8c32386c1f2d4166b6ba026b95eba412 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-8c32386c1f2d4166b6ba026b95eba4122025-08-20T03:47:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01203e031749010.1371/journal.pone.0317490Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults.Huakai WangChao ZhangYuxin SunSirui SunZhe WangHonggang Xiang<h4>Background</h4>The precise link between dietary consumption of n-3 and n-6 fatty acids and hyperuricemia remains equivocal. Accordingly, the purpose of the current investigation is to clarify any possible associations between the consumption of n-3 and n-6 fatty acids and hyperuricemia in the context of American adults.<h4>Materials and methods</h4>The present investigation employed a cross-sectional design, comprising a sample of 21,120 American adults above the age of 20 from the National Health and Nutrition Examination Survey (NHANES) waves between 2007 and 2016. The dietary consumption of n-3 and n-6 fatty acids was measured through two 24-h dietary recall interviews. To assess the relationships of dietary consumption of n3 and n6 fatty acids with hyperuricemia, we applied multivariable logistic regression, t tests, chi-square tests, and restricted cubic spline. To determine the robustness of our findings, sensitivity analyses were also carried out.<h4>Results</h4>The results of the multivariable logistic regression models indicated a significant correlation between dietary consumption of n3 and n6 fatty acids and hyperuricemia. The ORs with 95% CIs of hyperuricemia for the highest tertile versus lowest tertile of dietary consumption of n3 and n6 fatty acids were 0.76 (0.66, 0.88) (p < 0.001) and 0.72 (0.64, 0.82) (p < 0.001), respectively. Moreover, dose‒response analyses revealed a linear relationship between n-3 and n-6 fatty acid consumption and the risk of hyperuricemia.<h4>Conclusion</h4>The findings of this study indicate a significant inverse correlation between the dietary consumption of n3 and n6 fatty acids and hyperuricemia in the US adult population. Notably, there was no significant relationship between the n6:n3 ratio and hyperuricemia.https://doi.org/10.1371/journal.pone.0317490 |
| spellingShingle | Huakai Wang Chao Zhang Yuxin Sun Sirui Sun Zhe Wang Honggang Xiang Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults. PLoS ONE |
| title | Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults. |
| title_full | Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults. |
| title_fullStr | Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults. |
| title_full_unstemmed | Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults. |
| title_short | Inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults. |
| title_sort | inverse association of dietary consumption of n3 and n6 fatty acids with hyperuricemia among adults |
| url | https://doi.org/10.1371/journal.pone.0317490 |
| work_keys_str_mv | AT huakaiwang inverseassociationofdietaryconsumptionofn3andn6fattyacidswithhyperuricemiaamongadults AT chaozhang inverseassociationofdietaryconsumptionofn3andn6fattyacidswithhyperuricemiaamongadults AT yuxinsun inverseassociationofdietaryconsumptionofn3andn6fattyacidswithhyperuricemiaamongadults AT siruisun inverseassociationofdietaryconsumptionofn3andn6fattyacidswithhyperuricemiaamongadults AT zhewang inverseassociationofdietaryconsumptionofn3andn6fattyacidswithhyperuricemiaamongadults AT honggangxiang inverseassociationofdietaryconsumptionofn3andn6fattyacidswithhyperuricemiaamongadults |