Thyroid testing in primary hypothyroidism
Thyroid hormones regulate essential metabolic processes and development. The hypothalamic–pituitary–thyroid axis regulates hormone production, with thyroid-stimulating hormone (TSH) levels being a key indicator of thyroid function in primary hypothyroidism. This therapeutics letter emphasises a TSH-...
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| Format: | Article |
| Language: | English |
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AOSIS
2025-06-01
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| Series: | African Journal of Primary Health Care & Family Medicine |
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| Online Access: | https://phcfm.org/index.php/phcfm/article/view/5043 |
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| _version_ | 1849426969166348288 |
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| author | Anshula Ambasta Guillaume Grenet Jessica Otte Wade Thompson Kenneth Bassett Thomas Perry |
| author_facet | Anshula Ambasta Guillaume Grenet Jessica Otte Wade Thompson Kenneth Bassett Thomas Perry |
| author_sort | Anshula Ambasta |
| collection | DOAJ |
| description | Thyroid hormones regulate essential metabolic processes and development. The hypothalamic–pituitary–thyroid axis regulates hormone production, with thyroid-stimulating hormone (TSH) levels being a key indicator of thyroid function in primary hypothyroidism. This therapeutics letter emphasises a TSH-centred approach to the diagnosis and management of primary hypothyroidism (dysfunction at the level of the thyroid gland) in adults. It discourages routine thyroid function screening in asymptomatic individuals due to a lack of demonstrated benefit and potential harm from overdiagnosis and overtreatment. It outlines appropriate diagnostic strategies, including when to use TSH, free T4 (thyroxine), and free T3 (triiodothyronine) tests, and outlines indications for antibody testing. Special considerations are provided for subclinical hypothyroidism and hypothyroidism during pregnancy. |
| format | Article |
| id | doaj-art-8c2f2c3d4615411bb702d2f629e32d75 |
| institution | Kabale University |
| issn | 2071-2928 2071-2936 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | AOSIS |
| record_format | Article |
| series | African Journal of Primary Health Care & Family Medicine |
| spelling | doaj-art-8c2f2c3d4615411bb702d2f629e32d752025-08-20T03:29:10ZengAOSISAfrican Journal of Primary Health Care & Family Medicine2071-29282071-29362025-06-01171e1e410.4102/phcfm.v17i1.50431273Thyroid testing in primary hypothyroidismAnshula Ambasta0Guillaume Grenet1Jessica Otte2Wade Thompson3Kenneth Bassett4Thomas Perry5Department of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, VancouverDepartment of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, VancouverDepartment of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, VancouverDepartment of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, VancouverDepartment of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, VancouverDepartment of Anaesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, VancouverThyroid hormones regulate essential metabolic processes and development. The hypothalamic–pituitary–thyroid axis regulates hormone production, with thyroid-stimulating hormone (TSH) levels being a key indicator of thyroid function in primary hypothyroidism. This therapeutics letter emphasises a TSH-centred approach to the diagnosis and management of primary hypothyroidism (dysfunction at the level of the thyroid gland) in adults. It discourages routine thyroid function screening in asymptomatic individuals due to a lack of demonstrated benefit and potential harm from overdiagnosis and overtreatment. It outlines appropriate diagnostic strategies, including when to use TSH, free T4 (thyroxine), and free T3 (triiodothyronine) tests, and outlines indications for antibody testing. Special considerations are provided for subclinical hypothyroidism and hypothyroidism during pregnancy.https://phcfm.org/index.php/phcfm/article/view/5043diagnostic testshypothyroidismmass screeningoverdiagnosisthyroid function testspregnancythyroid diseases. |
| spellingShingle | Anshula Ambasta Guillaume Grenet Jessica Otte Wade Thompson Kenneth Bassett Thomas Perry Thyroid testing in primary hypothyroidism African Journal of Primary Health Care & Family Medicine diagnostic tests hypothyroidism mass screening overdiagnosis thyroid function tests pregnancy thyroid diseases. |
| title | Thyroid testing in primary hypothyroidism |
| title_full | Thyroid testing in primary hypothyroidism |
| title_fullStr | Thyroid testing in primary hypothyroidism |
| title_full_unstemmed | Thyroid testing in primary hypothyroidism |
| title_short | Thyroid testing in primary hypothyroidism |
| title_sort | thyroid testing in primary hypothyroidism |
| topic | diagnostic tests hypothyroidism mass screening overdiagnosis thyroid function tests pregnancy thyroid diseases. |
| url | https://phcfm.org/index.php/phcfm/article/view/5043 |
| work_keys_str_mv | AT anshulaambasta thyroidtestinginprimaryhypothyroidism AT guillaumegrenet thyroidtestinginprimaryhypothyroidism AT jessicaotte thyroidtestinginprimaryhypothyroidism AT wadethompson thyroidtestinginprimaryhypothyroidism AT kennethbassett thyroidtestinginprimaryhypothyroidism AT thomasperry thyroidtestinginprimaryhypothyroidism |